疏风解毒胶囊联合阿比多尔治疗新型冠状病毒肺炎的回顾性研究

Observation on clinical effect of Shufeng Jiedu Capsule combined with Arbidol Hydrochloride Capsule in treatment of COVID-19

目的回顾性研究分析疏风解毒胶囊联合阿比多尔治疗新型冠状病毒肺炎(COVID-19)的临床疗效。方法选取2020年1月31日—2020年2月11日于COVID-19定点收治医院亳州市人民医院诊断并治疗的COVID-19患者70例,按治疗方法的不同,分为联合用药组(40例)和阿比多尔组(30例),两组均予常规阿比多尔口服,联合用药组在此基础上予口服疏风解毒胶囊治疗,疗程10 d。对比两组患者的退热时间及干咳、鼻塞、流涕、咽痛、乏力、腹泻等症状消失时间,比较两组患者的新型冠状病毒(SARS-Co V-2)转阴率及转阴时间。结果联合用药组患者退热时间及干咳、鼻塞、流涕、咽痛、乏力、腹泻消失时间均较阿比多尔组显著缩短(P<0.05),治疗10 d后,联合用药组患者治愈出院6例,阿比多尔组出院1例;第10天复查咽拭子,联合用药组12例1次阴性、阿比多尔组7例1次阴性;联合用药组SARS-Co V-2转阴时间较阿比多尔组显著缩短(P<0.05)。结论疏风解毒胶囊联合阿比多尔治疗COVID-19优于单用阿比多尔,能显著缩短患者临床症状的好转时间和SARS-Co V-2转阴时间。

Objective To observe the clinical effect of Shufeng Jiedu Capsule combined with Arbidol Hydrochloride Capsule in the treatment of COVID-19.Methods From January 31,2020 to February 11,2020,70 patients with COVID-19 diagnosed and treated in Bozhou people’s hospital were selected.According to the different treatments,they were divided into two groups:40 patients in combination group and 30 patients in Arbidol Hydrochloride Capsule group.Patients in both groups were given routine Arbidol Hydrochloride Capsule orally.On this basis,the combination group was given oral Shufeng Jiedu Capsule for 10 d.The antipyretic time and the disappearance time of dry cough,nasal congestion,runny nose,sore throat,fatigue,diarrhea and other symptoms of patients in two groups were compared.The negative conversion ratio and negative conversion time of novel coronavirus(SARS-CoV-2)were also compared between two groups of patients.Results There were significant differences in antipyretic time,the disappearance time of dry cough,nasal congestion,runny nose,pharyngeal pain,fatigue,diarrhea,and novel coronavirus negative conversion time in the combination treatment group compared with the control group(P<0.05).The negative conversion time of combination treatment group was significantly shorter than Arbidol Hydrochloride Capsule group(P<0.05).Conclusion The combination of Shufeng Jiedu Capsule and Arbidol Hydrochloride Capsule was better than Arbidol Hydrochloride Capsule alone in the treatment of COVID-19,which could significantly shorten the symptoms improvement time and negative conversion time of the clinical patients.