中药防治细胞因子风暴的研究进展

Research progress on prevention and treatment of cytokine storm with traditional Chinese medicine

细胞因子风暴是机体对外界刺激产生的一种过激免疫反应,其发病机制复杂、疾病进展迅速、死亡率高。在此次新型冠状病毒肺炎(COVID-19)疫情中,患者病情急剧恶化与体内爆发的细胞因子风暴密切相关,《新型冠状病毒感染的肺炎诊疗方案(试行第六版)》亦给出了中医药治疗方案。从细胞因子风暴的源头、过程、危害出发,综述了中药在抗原清除、免疫调节、组织保护等方面的药理作用,探讨了中西医结合临床治疗多种肺炎的优势,阐明了中药对防治细胞因子风暴的贡献,为临床治疗提供有价值的用药指导。

Cytokine storm is an excessive immune process when the body is stimulated.The disease progresses rapidly with a high mortality and complicated pathogenesis.In the outbreak of coronavirus disease 2019(COVID-19),the rapid deterioration of the condition of patient is closely related to the outbreak of cytokine storm in the body.The sixth edition of Diagnosis and Treatment of Novel Coronavirus Pneumonia also provides a traditional Chinese medicine treatment plan.This paper reviewed the pharmacological effects of traditional Chinese medicine in antigen clearance,immune modulation and tissue protection based on the source,process and harm of cytokine storm.Furthermore,traditional Chinese medicine is contributive in prevention and treatment of cytokine storm,which can provide valuable medication guidance for the treatment combining traditional Chinese and Western medicine in clinic.