基于9种成分测定的厚朴炮制过程质量传递规律研究

Study on quality transfer law of Magnoliae Officinalis Cortex in processing based on nine components determination

目的揭示厚朴姜制的科学内涵,规范炮制生产工艺和临床合理用药。方法在固定厚朴药材采集部位、炮制工艺、人员、设备和环境等影响因素的基础上,以9种化学成分紫丁香苷、木兰箭毒碱、木兰苷B、木兰花碱、木兰苷A、和厚朴酚、厚朴酚、辣薄荷基厚朴酚、β-桉叶醇含量变化为指标,研究厚朴炮制过程质量传递规律。结果在厚朴药材炮制为净厚朴、姜厚朴过程中,酚类成分含量略有升高,生物碱类成分含量显著下降,苷类成分含量呈递减的趋势,其中木兰苷B含量显著下降,而木兰苷A和紫丁香酚苷的含量无显著变化,β-桉叶醇含量无显著变化。结论初步探讨了厚朴炮制过程中多种化学成分的质量传递规律,为厚朴炮制工艺的质量控制体系建立和厚朴饮片的质量提升提供参考。

Objective To reveal the scientific connotation of ginger-processed Magnoliae Officinalis Cortex(MOC), and standardize the production process and offer the theoretical base for clinical medication. Methods This paper studied on quality transfer law of MOC in processing based on the determination of nine chemical components, including syringing, magnocurarine, magnolin B, magnoflorine, magnolin A, honokiol, magnolol, piperitylmagnolol, and β-eudesmol, through controlling factors such as part of sample collection, processing technology, personnel, equipment and environment. Results The results showed that the content of phenolic components was increased slightly, the content of alkaloids was decreased significantly, and the content of glycosides was decreased, and the content of magnoloside B was decreased significantly in the process of preparation for MOC and ginger-processed MOC. Moreover, there was no significant difference in the content of magnoloside A, syringin, and volatile oil represented by β-eudesmol. Conclusion This study preliminarily explored the quality transfer law of multi-components in the processing of MOC, and provided reference for the establishment of the quality control system of the crude drug processing technology and improvement of the quality of products.