雷公藤治疗类风湿性关节炎研究进展

Research progress of Tripterygium wilfordii in treatment of rheumatoid arthritis

类风湿关节炎(RA)是一种以滑膜持续炎症和关节软骨及骨质破坏为特征的慢性自身免疫性疾病,随着人口老龄化不断加剧,RA的发病率逐年升高,公共卫生负担日趋严重。雷公藤具有祛风通络、除湿止痛、解毒杀虫的功效,临床常用于治疗多种自身免疫性疾病、肿瘤及皮肤病等,尤其在治疗RA方面疗效显著。从实验药理学与临床研究2个方面系统综述近年来雷公藤治疗RA的最新研究进展,包括雷公藤单味药应用、雷公藤与其他中药配伍应用以及雷公藤与化学药联合用药,以期促进雷公藤用于RA治疗的创新药物研发与临床合理有效应用。

Rheumatoid arthritis(RA)is a chronic autoimmune disease characterized by persistent synovitis and destruction of articular cartilage and bone.With the aging of the population,the incidence of RA is increasing year by year and the burden of public health is becoming more and more serious.Tripterygium wilfordii has the effects of dispelling wind and dredging collaterals,dehumidifying and relieving pain,detoxification and insecticide.It is often used in the treatment of various autoimmune diseases,tumors and skin diseases in clinic,and the prominent effect is observed in the treatment of RA especially.This review systematically summarizes and discusses the latest research progress of T.wilfordii in the treatment of RA in the aspects of experimental pharmacology and clinical research,including its single application,the compatible application with other Chinese materia medica,and the combination of Western medicine,which is expected to promote the innovative drug development and more reasonable and effective clinical application of T.wilfordii in the treatment of RA.