休克小肠再灌注损伤的研究 Ⅲ.血管活性药物对再灌注损伤的影响

Studies on reperfusion damage of shocked intestine Ⅲ. Effect of vasoaetive agents on the reperfusion damage

结扎家兔SMA 1小时后,颈动脉血流经灌流泵以90mmHg压力再灌注SMA 2小时。使用NE显著加重组织再灌注损伤,而使用POB虽然SMA血流量增加到原水平的146.5±3.7%,但仍发生了严重的小肠出血水肿,绒毛坏死等再灌注损伤。本文讨论了晚期休克时血管活性剂对再灌注损伤的影响。

Reperfusion damage was observed on rabbits under reperfusion SMA with blood from its own carotid artery via perfusion pump at 90 mmHg for 2h after SMA occlusion for one hour.with addition of NE in the reperfusion fluid significantly aggravated the reperfusion injury.Reperfusion with POB although increased SMA blood to 146.5±3.7%of its orginal levels,the animals,however,developed severe reperfusion damage,including intestinal hemorrhage and edema,intestinal villus necrosis etc.The influence of vasoactive agents on reperfusion injury in late shock was discussed.