间断电针对家兔乳汁腹膜炎性发热效应的抑制作用

The inhibition of intermittent electric acupuncture on fever in milk-induced peritonitis of rabbits

用体重1.8—2.9公斤的24只封闭群新西兰白兔,随机分成三组,每组8只。第一组腹腔注射无热原生理盐水5ml/kg,作为对照;第二组腹腔注射高压(126℃,30分钟)灭菌牛奶5ml/kg;第三组与第二组同样腹腔注射牛奶一小时后针刺百会穴,针刺半小时后,间断通电。通电5分钟即停止通电10分钟,共通电6次。注射前2小时及注射后3.5小时内,每隔10分钟测一次直肠温度。然后比较各组腹腔注射后3.5小时的体温反应指数(TRI3.5)的均数与体温反应高峰(△T)的均数。实验结果如下:TRI3.5的(?)±SD,为:第一组0.22±0.27;第二组3.40±2.39;第三组0.63±0.52;△T的(?)±SD为:第一组0.13±018℃;第二组1.14±0.39℃,第三组0.41±0.34℃。经F检验与Q检验比较各组均数,均为P<0.01。结果表明间断电针能明显抑制无菌乳汁腹膜炎性发热,从而也说明无菌乳汁腹膜炎性发热是对针刺疗法敏感的发热模型。适用于实验治疗及其原理的研究。

Twenty four albino New Zealand rabbits weighing between 1.8 to 3.5 kg were divided into three groups at random,eight in each group respectively.5ml/kg autoclaved(126℃,30 min.)milk was given intra-peritoneally to group B.For group C,one hour after the same milk injection as for group B,an acupuncture-needle was put into"Baihui Point"for half an hour then followed by six electrical stimulations at the same point of five minutes alternately with ten minutes intervals.To group A only 5 ml/kg pyrogen-free normal saline was given for control.Rectal temperatures were recorded every ten minutes for two hours before the injection and for three and half hours after.The mean of recorded thermal response index(TRI)and the thermal response peak(△T)of each group after injection were taken for comparison.The results showed by TRI(?)±SD are as follows:Control 0.22±0.27,Group B 3.40±2.39 and group C 0.63±0.52;and by(?)±SD of△T:Control 0.13±0.18℃,group B 1.14±0.39℃and group C 0.40±0.34℃.The mean of each group checked by F test and Q test gives a significant difference(P<0.01).The results obtained by the present work elucidated that the intermittent electric acupuncture obviously inhibits the fever in milk-induced peritonitis of rabbits which is considered being a sensitive model for experimental research of acupuncture therapy.