慢性肾脏病人群握力下降的相关因素分析

Lower handgrip strength in chronic kidney disease

目的探讨我国中老年慢性肾脏病(chronic kidney disease,CKD)人群握力下降的发生及相关因素。方法数据来自中国健康与养老追踪调查2015年数据,以CKD-EPIcr-cys2021公式计算估测肾小球滤过率(estimated glomerular filtration rate,eGFR),eGFR<60 mL/(min·1.73 m^(2))诊断CKD。根据亚洲肌少症工作组2019专家共识,男性握力<28 kg,女性握力<18 kg定义为握力下降。logistic回归分析握力下降的相关因素。结果885例CKD纳入研究,平均年龄69岁,握力下降发生率26.7%。≥65岁(O R=3.092,95%C I为1.980~4.830)、胱抑素C(cystatin C,CysC)升高(O R=1.738,95%C I为1.209~2.497)、独居(O R=1.471,95%C I为1.028~2.104)、城市居住(O R=1.396,95%C I为1.002~1.945)同握力下降相关。结论CKD人群握力下降发生率高,高龄、高胱抑素C、独居、城市居住与握力下降发生相关。

Objective To investigate the prevalence of lower handgrip strength and risk factors in middle-aged and elderly with chronic kidney disease in China.Methods The data comes from the China Health and Retirement Longitudinal Study in 2015.The estimated glomerular filtration rate(eGFR)was calculated using the CKDEPIcr-cys2021 formula and CKD was defined as eGFR<60 mL/(min·1.73 m^(2)).According to the 2019 expert consensus of the Asian Working Group of Sarcopenia,grip strength of less than 28 kg for males and less than 18kg for females was defined as a lower handgrip strength.logistic regression were used to identify risk factors for lower handgrip strength in CKD.Results A total of 885 participants were included,with an average age of 69 years old.The prevalence of lower handgrip strength in CKD was 26.7%.Over 65 years old(O R=3.092,95%CI 1.980-4.830),cystatin C(O R=1.738,95%CI 1.209-2.497),living alone(O R=1.471,95%CI 1.028-2.104),and living in urban areas(O R=1.396,95%CI 1.002-1.945)were associated with lower handgrip strength.Conclusions The prevalence of lower handgrip strength in CKD was high.Aged,higher cystatin C,living alone,and living in urban areas were associated with lower handgrip strength in CKD.