2011—2021年重庆市九龙坡区结直肠癌疾病负担趋势分析

Trend analysis of colorectal cancer disease burden in Jiulongpo district of Chongqing from 2011 to 2021

目的分析重庆市九龙坡区结直肠癌(colorectal cancer,CRC)疾病负担特征及变化趋势,为CRC的防治提供建议。方法收集2011—2021年重庆市九龙坡区CRC发病死亡资料,采用SPSS 19.0统计软件分析CRC的粗发病率、标准化发病率(age standardized rates of incidence by Chinese standard population,ASRIC)、死亡率、标准化死亡率(age standardized rates of mortality by Chinese standard population,ASRMC)、伤残调整寿命年(disability adjusted life year,DALY)、早死所致的寿命损失年(years of life lost with premature death,YLL)、伤残所致寿命损失年(years lived with disability,YLD)等指标。利用χ^(2)检验比较不同性别间的发病率和死亡率;趋势变化用年度变化百分比(annual percent change,APC)表示,用t检验分析APC统计学差异。结果2011—2021年重庆市九龙坡区CRC粗发病率、ASRIC、粗死亡率及ASRMC分别为31.26/10万、21.40/10万、16.38/10万和10.65/10万,分别以年均3.67%(t=5.83,P<0.05)、2.12%(t=3.65,P<0.05)、8.65%(t=8.36,P<0.05)和6.18%(t=5.97,P<0.05)上升;历年男性发病率及死亡率均大于女性(P<0.05);2011—2021年重庆市九龙坡区CRC发病率和死亡率均随年龄增长而升高。CRC的YLD率、YLL率和DALY率分别为0.19‰、3.57‰和3.76‰,分别以4.71%(t=6.40,P<0.05)、7.25%(t=5.75,P<0.05)和7.04%(t=5.95,P<0.05)趋势上升;男性居民YLD率、YLL率和DALY率分别为0.24‰、4.68‰和4.92‰,均高于女性居民的0.15‰、2.47‰和2.62‰,女性CRC的YLL率、YLD率、DLAY率均呈上升趋势(P<0.05),而男性CRC疾病负担年度趋势变化无统计学意义(P>0.05);2011—2021年重庆区九龙坡区CRC疾病负担随年龄增长而升高。结论2011—2021年重庆市九龙坡区CRC的疾病负担仍较重,尤其是男性和老年人群,YLL率是疾病负担过重的主要原因。

Objective To analyze the characteristics and trend of disease burden of colorectal cancer in Jiulongpo District of Chongqing,so as to provide suggestions for prevention and treatment of colorectal cancer.Methods The data of colorectal cancer patient with newly diagnosed and dead in Jiulongpo District of Chongqing from 2011 to 2021 were collected.The morbidity,age standardized rates of incidence by Chinese standard population(ASRIC),mortality,age standardized rates of mortality by Chinese standard population(ASRMC),disability adjusted life year(DALY),years of life lost with premature death(YLL),years lived with disability(YLD)were analyzed by SPSS 19.0.The morbidity and mortality between the gender were compared byχ^(2)test,and the morbidity,ASRIC,mortality,ASRMC,DALY rate,YLL rate,YLD rate trend change were expressed by annual percent change(APC)and analyzed by t test.Results The crude morbidity,ASRIC,crude mortality and ASRMC of colorectal cancer were 31.26 per 100,000,21.40 per 100,000,16.38 per 100,000 and 10.65 per 100,000,and increased at an average annual rate of 3.67%(t=5.83,P<0.05)、2.12%(t=3.65,P<0.05)、8.65%(t=8.36,P<0.05)and 6.18%(t=5.97,P<0.05)separately in Jiulongpo district of Chongqing from 2011 to 2021.The morbidity and mortality of male were higher than that of female(P<0.05).Morbidity and mortality all increased with age.The annual average YLD rate,YLL rate and DALY rate of colorectal cancer were 0.19‰、3.57‰and 3.76‰respectively,and the trend of increasing was 4.71%(t=6.40,P<0.05)、7.25%(t=5.75,P<0.05)and 7.04%(t=5.95,P<0.05)respectively.The YLL rate,YLD rate and DLAY rate in male residents(0.24‰、4.68‰and 4.92‰)were all higher than those in female residents 0.15‰、2.47‰and 2.62‰.The YLL rate,YLD rate and DLAY rate of female patients with colorectal cancer showed an increasing trend(P<0.05),while the annual trend of male patients with colorectal cancer disease burden had no statistical significance(P>0.05).Disease burden increased with age.Conclusion The Disease burden of colorectal cancer was still heavy,especially for male and the elderly,and YLL rate was the main reason of overburden in Jiulongpo District of Chongqing from 2011 to 2021.