1年随访对肥胖或非肥胖糖尿病控制状况评价

One-year follow-up evaluation of disease control in obese and non-obese patients with diabetes

目的分析1年随访对肥胖或非肥胖2型糖尿病患者疾病控制的影响,为糖尿病患者管理工作提供理论支持。方法选取韶关市某区糖尿病眼病队列研究中参加2020年随访且进行了血生化检查的2723例2型糖尿病患者作为研究对象。首先,根据体质量指数(body mass index,BMI)将患者分成肥胖组和非肥胖组,然后,再根据是否参加了2019年筛查随访分为新入组和随访组,分别在肥胖组和非肥胖组中比较新入组和随访组血糖、血脂、肝功能指标和肾功能指标之间有无差异。结果在肥胖2型糖尿病患者中,随访组与新入组糖化血红蛋白(haemoglobin A1c,HbA1c)和空腹血糖(fasting plasma glucose,FPG)比较,差异有统计学意义(P<0.05),随访组HbA1c和FPG均比新入组低。在非肥胖2型糖尿病患者中,随访组与新入组甘油三酯(triglycerides,TG)差异有统计学意义(P=0.042),随访组TG比新入组低。结论随访对糖尿病患者具良好的疾病控制作用,尤其是在血糖和血脂方面。因此,应积极开展糖尿病患者定期随访工作。

Objective To analyze the 1-year follow-up evaluation on disease control in obese and nonobese patients with type 2 diabetes mellitus,and to provide a theoretical support for diabetes management.Method A total of 2723 patients with type 2 diabetes mellitus who were followed in 2020 and underwent blood testing in a cohort study of diabetic eye disease in Shaoguan were selected as subjects.First,the patients were divided into obese and non-obese groups according to the body mass index,then divided into newly-enrolled and follow-up groups based on participation in the 2019 screening follow-up evaluation.To compare the differences between the newly-enrolled and follow-up groups with respect to blood glucose,blood lipids,and liver and kidney function indicators.Results In obese patients with type 2 diabetes mellitus,there was a statistically significant difference between the follow-up and newly-enrolled group in hemoglobin A1c(HbA1c,P=0.014)and fasting plasma glucose(FPG,P=0.037)levels.The FPG and HbA1clevels in the follow-up group were lower than the newly-enrolled group.In non-obese patients with type 2diabetic mellitus,there were statistically significant differences in triglycerides(TG)levels between the follow-up and newly-enrolled groups(P=0.042).The TG level in the follow-up group was lower than the newlyenrolled group.Conclusion The follow-up evaluation has a favorable disease control effect in diabetic patients,especially with respect to the blood glucose and blood lipids levels.Therefore,regular follow-up evaluations of diabetic patients should be carried out.