冠心病患者血清Ghrelin、SUA、MPV表达及与PCI后不良心血管事件关系

Expression of serum ghrelin,SUA,and MPV in CHD patients and the relationship with adverse cardiovascular events after PCI

目的探讨冠心病患者经皮冠脉介入术(percutaneous coronary intervention,PCI)后主要不良心血管事件(major adverse cardiovascular events,MACE)与血清胃促生长素(ghrelin)、血尿酸(serum uric acid,SUA)、平均血小板体积(mean platelet volume,MPV)的关系。方法选取四川大学华西广安医院2018年7月—2020年7月实施PCI手术治疗的160例冠心病患者进行回顾性分析。根据患者PCI术后随访6个月内是否发生不良心血管事件分为MACE组58例和未发生MACE的对照组102例。比较两组PCI术后第7天的Ghrelin、SUA、MPV、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、空腹血糖(fasting plasma glucose,FPG)、收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)。结果MACE组和对照组的HDL-C、LDL-C、TC、FPG、SBP、DBP测定值,差异无统计学意义(P>0.05)。MACE组血清TG水平显著高于对照组,差异有统计学意义(P<0.05)。MACE组PCI术后第7天的SUA、MPV显著高于对照组,而Ghrelin显著低于对照组,差异有统计学意义(P<0.05)。采用logistic回归分析法结果显示TG、SUA、MPV升高,Ghrelin水平降低是冠心病患者PCI术后发生MACE的独立危险因素,差异有统计学意义(P<0.05)。结论冠心病患者PCI术后Ghrelin水平降低、SUA、MPV升高可能与MACE的发生具有一定的关系。

Objective To determine the relationship between adverse cardiovascular events and ghrelin,SUA,and MPV after percutaneous coronary intervention(PCI)in patients with coronary heart disease.Methods One hundred sixty CHD patients who underwent PCI from July 2018 to July 2020 in west China Guang’an Hospital of Sichuan University were selected for retrospective analysis.Patients were placed in the major adverse cardiovascular events(MACE;n=58)and no MACE groups(control;n=102).within 6months after PCI.The following were measured on day 7 after PCI and compared between the 2 groups:ghrelin;SUA;MPV;HDL-C;LDL-C;TG;TC;FPG;SBP;and DBP.Results There was no significant differences in HDL-C,LDL-C,TC,FPG,SBP,and DBP between the MACE and control groups(P>0.05).The serum TG level in the MACE group was significantly higher than the control group(P<0.05).On the 7th day after PCI,the MACE group had a significantly higher SUA and MPV than the control group,while ghrelin was significantly lower than the control group(P<0.05).Logistic regression analysis showed that the increase in TG,SUA,and MPV,and the decrease in ghrelin were independent risk factors for MACE in CHD patients after PCI(P<0.05).Conclusion A decrease in ghrelin and an increase in SUA and MPV after PCI in CHD patients may be related to the occurrence of MACE.