艾司西酞普兰联合氨磺必利治疗阴性症状为主的精神分裂症的临床疗效评价

Clinical effect of escitalopram combined with amisulpride in the treatment of schizophrenia with negative symptoms

目的探讨艾司西酞普兰联合氨磺必利治疗阴性症状为主的精神分裂症的临床效果。方法选取2015年1月至2017年1月徐州市民政精神病医院收治的阴性症状为主的83例精神分裂症住院患者作为研究对象,根据随机数字表法分为对照组42例和观察组41例。其中,对照组予以氨磺必利治疗,观察组予以艾斯西酞普兰联合氨磺必利治疗,共治疗8周。比较两组患者治疗有效率,治疗前后阴性症状量表(SANS)、神经心理学(Stroop实验)评分,治疗期间不良反应及预后情况。结果观察组治疗总有效率为87.70%,高于对照组的71.43%,差异有统计学意义(P<0.05)。两组患者治疗后SANS量表评分与总分均低于治疗前,且观察组患者治疗后SANS量表评分与总分均低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者Stroop实验评分高于治疗前,且观察组患者治疗后Stroop实验评分高于对照组,差异有统计学意义(P<0.05)。观察组患者复发率为12.20%(5/41),低于对照组的28.57%(12/42),差异有统计学意义(P<0.05)。结论艾司西酞普兰联合氨磺必利治疗阴性症状为主的精神分裂症效果显著,预后较好,可有效改善患者临床症状及执行功能。

Objective To explore the clinical effect of escitalopram combined with amisulpride in the treatment of schizophrenia with negative symptoms.Methods From January 2015 to January 2017,totally 83 schizophrenic patients with negative symptoms were enrolled to this study,whom were divided into two groups.The control group was received amisulpride,while the observation group was received escitalopram plus amisulpride.Both of them were treated for 8 weeks.The effective,socores of Scale for Assessment of Negative Symptoms(SANS),Stroop test scores,and adverse reactions were compared between two groups.Results The treatment effective rate of the observation group was87.70%which was higher than that of the control group(71.43%),and the difference was statistically significant(P<0.05).After treatment,the scores of all indicators and their total scores of SANS scale in the two groups were lower than those before treatment(P<0.05);all the scores in the observation group were lower than those in the control group(P<0.05).The Stroop test scores of the two groups after treatment were higher than those before treatment(P<0.05);the Stroop test score of the observation group after treatment was higher than that of the control group(P<0.05).The recurrence rate was 12.20%(5/41)in the observation group and 28.57%(12/42)in the control group,and there was significant difference between the two groups(P<0.05).Conclusion Escitalopram combined with amisulfapride is effective in the treatment of schizophrenia with negative symptoms.It has a good prognosis and can effectively improve the clinical symptoms and executive function of patients.