血管免疫母细胞性T细胞淋巴瘤患者生存质量及影响因素分析

Analysis of the influencing factors of quality of life in patients with angioimmunoblastic T-cell lymphoma

目的探讨血管免疫母细胞性T细胞淋巴瘤(AITL)患者生存质量状态,分析其相关影响因素。方法选取182例AITL患者作为研究对象,采用SF-36量表进行问卷调查,对患者生存质量进行评分,将生存质量总分≥72分定义为生存质量好,<72分为生存质量差,并收集患者相关资料,筛选出AITL患者生存质量的影响因素。结果患者治疗前生存质量总平均分为(69.32±6.82)分,治疗后总平均分为(101.62±8.65)分。生存质量好组与生存质量差组在文化程度、疾病认知度、家庭收入、疾病复发、婚姻状况、居住情况、淋巴结肿大、贫血和乳酸脱氢酶方面差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示,文化程度(β=2.225,OR=10.596,95%CI 6.363~29.853)、疾病认知度(β=0.992,OR=3.103,95%CI 1.256~9.285)、家庭收入(β=2.832,OR=12.696,95%CI 4.663~32.593)、疾病复发(β=3.256,OR=15.526,95%CI 3.925~28.533)、婚姻情况(β=2.069,OR=18.516,95%CI 4.355~30.563)、居住情况(β=2.005,OR=13.821,95%CI 4.189~33.253)、淋巴结肿大(β=1.325,OR=10.031,95%CI 2.133~22.683)和乳酸脱氢酶(β=6.358,OR=11.852,95%CI 5.278~26.360)是AITL患者生存质量的影响因素(P<0.05)。结论AITL患者生存质量相对较差,文化程度、疾病认知度、经济收入、疾病复发、婚姻状况、居住情况、淋巴结肿大和乳酸脱氢酶升高对患者的生存质量影响较大。

Objective To measure and assess the quality of life in patients with angioimmunoblastic Tcell lymphoma(AITL),and analyze its related influencing factors.Method Totally 182 patients with AITL were selected as the research objects.The patients were divided into two groups according to their quality of life measured by SF-36:SF-36≥72 group and SF-36<72 group.Data of the patients were collected to screen out the main influencing factors of quality of life in patients with AITL.Results The total score of quality of life before treatment was(69.32±6.82)and that was(101.62±8.65)after treatment.There were significant differences in education level,disease awareness,family income,disease recurrence,marital status,living conditions,lymphadenopathy,anemia and lactate dehydrogenase(LDH)between SF-36≥72 group and SF-36<72 group(P<0.05).Logistic regression analysis showed that education(β=2.225,OR=10.596,95%CI 6.363-29.853),disease awareness(β=0.992,OR=3.103,95%CI 1.256-9.285),family income(β=2.832,OR=12.696,95%CI 4.663-32.593),disease recurrence(β=3.256,OR=15.526,95%CI 3.925-28.533),marital status(β=2.069,OR=18.516,95%CI 4.355-30.563),living conditions(β=2.005,OR=13.821,95%CI 4.189-33.253),lymphadenopathy(β=1.325,OR=10.031,95%CI2.133-22.683)and LDH(β=6.358,OR=11.852,95%CI 5.278-26.360)were the related factors of quality of life in patients with AITL(P<0.05).Conclusion The quality of life of patients with AITL is relatively poor.The education level,disease awareness,economic income,disease recurrence,marital status,living conditions lymphadenopathy and LDH may affect the quality of life of patients.