基于纳米材料光谱分析法检测抗坏血酸的研究进展

Research Progress on Detection of Ascorbic Acid by Nanomaterial-Based Spectral Analysis Method

抗坏血酸(Ascorbic Acid,AA)是一种人们熟知的生物小分子,参与维系机体内各生理及生化过程的正常进行。许多研究表明,多种疾病如贫血、痛风及动脉粥样硬化等与其浓度变化相关。AA对体内诸多生物分子的吸收代谢及合成过程具有的重要影响,在保健品、食品、化妆品及药物制剂等领域具有广泛应用。AA检测方法众多,其中,光谱分析法具备有快速、低成本和易于操作的优势。平均直径小于100 nm的纳米材料在光谱分析法中起到至关重要的作用。本文围绕量子点、金属纳米团簇/颗粒、纳米笼/棒/纤维材料、纳米片材料在内的几种纳米材料采用光谱分析法,尤其是荧光光谱法和紫外光谱法检测AA的研究现状进行介绍,同时讨论了不同种纳米材料的检测优势及存在问题。

Well-known as a biological small molecule,ascorbic acid(AA)is involved in maintaining the normal progress of physiological and biochemical processes in the body.Many researches have shown that a variety of diseases such as anemia,gout,and atherosclerosis are associated with changes in its concentration.AA has an important influence on the absorption,metabolism and synthesis of many biological molecules in the body,which has made it widely used in the fields of health care products,food,cosmetics and pharmaceutical preparations.Among the many detection methods of AA,spectral analysis has more advantages because of its fastness,low cost and easy operation.Nanomaterials with an average diameter of less than 100 nm play an important role in spectral analysis.In this article,several nanomaterials including quantum dots,metal nanoclusters/particles,nanocage/bar/fiber materials and nanosheet materials with the method of spectroscopy analysis,especially fluorescence spectrometry and ultraviolet spectroscopy,are introduced to detect AA in current research situation.The testing advantages and existing problems are discussed for different kinds of nanomaterials.