cGAS-STING在肿瘤转移中的研究进展

Research progress of cGAS-STING in tumor metastasis

环磷酸鸟苷-腺苷酸合成酶(cyclic GMP-AMP synthase,cGAS)-干扰素基因刺激因子(stimulator of interferon gene,STING)信号通路是细胞质内一条重要的免疫应答通路,通过识别胞浆DNA调节起始免疫和适应性免疫应答。研究表明,来自肿瘤自身的DNA和基因组不稳定性都能够激活cGAS-STING通路,促进或抑制肿瘤的发展及转移。本文主要从cGAS和STING的结构功能特点、通路转导调节、抑制剂/激动剂研究现状及其在肿瘤发生发展及转移中的作用等方面进行系统阐述,为临床开发靶向cGAS-STING的抗肿瘤新药提供理论依据,为肿瘤临床及肿瘤研究工作者提供参考。

Cyclic GMP-AMP synthase(cGAS)-stimulator of interferon gene(STING)signaling pathway as an essential immune response pathway in cytoplasm,can find cytoplasmic DNA to regulate the innate immune and adaptive immune response.Studies have shown that the signaling pathway can be activated by both tumor selfDNA and genomic instability,thus to promote or inhibit the development and metastasis of tumors.Therefore,the role of cGAS-STING in tumor genesis,development and metastasis will be systematically expounded from the structures,physiological functions,inhibitors and agonists of cGAS and STING as well as its pathway transduction regulation in this paper.The paper aims to offer theoretical basis and reference for targeting cGAS-STING antitumor drugs in clinical practice and cancer clinical and cancer research workers.