基于AMPK/mTOR通路的天然产物抗大肠癌研究进展

Research Progress in anti-Colorectal Cancer of Natural Compounds Based on AMPK/mTOR Signalling Pathway

大肠癌是严重危害人类健康的常见恶性消化系统肿瘤之一,目前临床上大肠癌的主要治疗手段是手术结合放化疗,但往往伴随着多种副作用。与此同时,越来越多的天然产物表现出良好的抗大肠癌活性,有望成为新型大肠癌治疗候选药物。AMP依赖的蛋白激酶(AMPK)是细胞内能量代谢的中心枢纽,可以通过抑制其下游靶标哺乳动物雷帕霉素靶蛋白(mTOR)而调控肿瘤细胞生长、增殖等。近年来,越来越多的研究显示一些天然产物能够通过调控AMPK/m TOR通路而发挥其抗大肠癌活性。围绕AMPK/mTOR信号通路在大肠癌中的作用及基于此通路的抗大肠癌天然产物的研究进展进行综述。

Colorectal cancer,one of the most common malignant tumors of the digestive system,is a major public health threat worldwide.At present,the main treatment for colorectal cancer is surgery combined with radiotherapy and chemotherapy,but it is often accompanied by various side effects.At the same time,some natural compounds with good anti-colorectal cancer activity are expected to become new drug candidates for colorectal cancer treatment.AMP-dependent protein kinase(AMPK),a central hub of intracellular energy metabolism,can regulate tumor cell growth and proliferation by inhibiting its downstream target mammalian rapamycin target protein(mTOR).In recent years,more and more studies have shown that some natural products exert their anti-colorectal cancer activity by regulating the AMPK/mTOR pathway.This article focuses on the role of AMPK/mTOR signalling pathway in colorectal cancer with a review of the research progress of anti-colorectal cancer natural products regulating AMPK/mTOR signalling pathway.