套索肽——一种可供多肽类药物设计和改造的多功能载体

Lasso Peptide——A Multifunctional Carrier for the Design and Modification of Peptide-based Therapeutics

套索肽是在细菌中发现的多肽类天然产物,是由核糖体合成并经过翻译后修饰产生的一类具有套索构型的生物活性肽,具有抗细菌或真菌的作用,或具有抗病毒或抗肿瘤的功能。套索肽一般无或具有极低的免疫原性。根据其所含二硫键数目和位置的不同,套索肽可分为4类。由于其特殊的套索结构,套索肽与线性肽相比具有极好的热稳定性和蛋白酶稳定性。套索肽已开始被用于医药、食品等领域,有望用作生物药物的载体,正在成为多肽类药物研发的热点。

Lasso peptides,natural products found in bacteria,are bioactive peptides belonging to a peculiar family of ribosomally synthesized and post-translationally modified peptides with an unusual lasso structure,an array of anti-bacterial or anti-fungal activity,and anti-viral or anti-tumor functions,with no or low immunogenicity.Lasso peptides can be classified into four types according to the numbers and positions of the disulfide bonds.Due to their particular threaded structure,lasso peptide presents remarkable thermal and proteolytic stability compared with linear peptide.Lasso peptide has been widely applied in the manufacturing of medicines and foods,and is expected to be used as delivery carrier of biologics,which has become a hot spot for the design of polypeptide drugs.