哌替啶药物成瘾风险及预防措施

Risk of pethidine addiction and preventive measures

目的:临床常用麻醉性镇痛药物对难以忍受躯体疼痛的患者止痛,然而麻醉性镇痛药的药物依赖也是不能回避的问题。方法:选取2019年10月至2020年3月于北京高新医院(专业戒毒医院)收治的35例因使用哌替啶产生药物依赖的患者,分析其使用哌替啶的原因、剂量、产生戒断的身体症状等。结果:研究发现哌替啶药物成瘾患者的平均年龄41岁,平均注射时间为5.6年。哌替啶用药原因以止痛(包括癌症相关疼痛)占比较大(45.7%)。结论:研究发现哌替啶的戒断症状严重程度比吗啡小,且自主神经症状不明显。

Objective:Narcotic analgesics are commonly used in clinic to relieve pain in patients with unbearable body pain.However,the withdrawal symptoms of narcotic drugs can not be avoided.Methods:From October 2019 to March 2020,35 patients with withdrawal symptoms due to pethidine were selected from Beijing Gaoxin Hospital(a professional hospital for drug addiction).The reasons,dosage and physical symptoms of withdrawal of pethidine were analyzed.Results:The mean age of pethidine addiction patients was 41 years old,and the mean injection time was 5.6 years.The reasons for pethidine′s use in internal medicine for pain relief(including cancer)accounted for a relatively large proportion(45.7%).Conclusion:The symptoms of withdrawal addiction of pethidine were less than that of morphine,and the symptoms of autonomic nerve were not obvious.