GRP94蛋白的生物学特性及其与肿瘤的关系研究进展

Research Progress on Biological Characteristics of GRP94 Protein and its Relationship with Tumors

葡萄糖调节蛋白94(GRP94)有多种其他生物学的功能,并与热休克蛋白90之间具有同源性。GRP94参与抗原受体的装备和抗原的加工和提呈,能促进DC成熟活化,在细胞凋亡和免疫应答中有重要的作用。GRP94的表达水平与肿瘤发展情况相关,并参与肿瘤免疫应答过程,肿瘤组织来源的GRP94结合有肿瘤特异性抗原多肽,能够诱导特异性抗肿瘤免疫,在肿瘤发生和进展之中也发挥着重大的作用。目前研究得到证实,GRP94-肽复合物疫苗对多种癌症早中期能起到保护性免疫的作用,应用GRP94-肽复合物疫苗治疗癌症的前景十分广阔。但GRP94-肽复合物疫苗对晚期肿瘤疗效不明确,还需进行大量临床研究。

Glucose regulatory protein 94(GRP94)has many biological functions and homology with heat shock protein 90.GRP94 participates in the equipment of antigen receptor and the processing and presentation of antigen,promotes the maturation and activation of DC,and plays an important role in apoptosis and immune response.The expression level of GRP94 is related to the development of tumors and participates in the process of immune response.GRP94 from tumors can induce specific anti-tumor immunity by binding with tumor-specific antigen polypeptide,which also plays an important role in tumorigenesis and progression.Current studies have confirmed that GRP94-peptide complex vaccine can play a protective immune role in the early and middle stages of various cancers,and the application of GRP94-peptide complex vaccine in cancer treatment has broad prospects.However,the efficacy of GRP94-peptide complex vaccine for advanced tumors is not clear,and a large number of further clinical studies are needed.