胃炎宁颗粒联合胶体果胶铋治疗慢性萎缩性胃炎的临床研究

Curative effect of Weiyanning Granules combined with colloidal bismuth pectin on chronic atrophic gastritis

目的探讨胃炎宁颗粒联合胶体果胶铋胶囊治疗慢性萎缩性胃炎的临床疗效。方法选取2017年4月—2018年4月在儋州市人民医院进行治疗110例慢性萎缩性胃炎患者作为研究对象,根据入院的顺序将患者分为观察组(55例)和对照组(55例)。对照组给予胶体果胶铋胶囊,2粒/次,4次/d;观察组在对照组的基础上口服胃炎宁颗粒,15 g/次,3次/d。两组均治疗4周。观察两组患者的临床疗效,同时比较两组治疗前后的症候积分、SF-36量表评分、血清炎性因子水平和血清学指标。结果经治疗,对照组有效率为85.45%,显著低于观察组的98.18%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组相关临床症候积分均显著降低(P<0.05),且以观察组最为明显(P<0.05)。治疗后,两组SF-36量表评分均显著提高(P<0.05),且以观察组最明显(P<0.05)。治疗后,两组在血清超敏C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、可溶性白细胞介素-2受体(s IL-2R)水平均显著改善(P<0.05),且观察组更为明显(P<0.05)。治疗后,两组血清前列腺素E2(PGE2)、血管内皮生长因子(VEGF)、胃泌素(GAS)、胃泌素-17(G-17)、生长抑素(SS)水平均显著改善(P<0.05),且观察组更明显(P<0.05)。结论胃炎宁颗粒联合胶体果胶铋胶囊治疗慢性萎缩性胃炎可有效改善患者临床症状,降低机体炎症反应和改善机体血清学指标水平,具有良好临床应用价值。

Objective To investigate the clinical efficacy of Weiyanning Granules combined with Colloidal Bismuth Pectin Capsules in treatment of chronic atrophic gastritis.Methods Patients(110 cases)with chronic atrophic gastritis were treated in Danzhou People’s Hospital from April 2017 to April 2018 were divided into observation group(55 cases)and control group(55 cases)according to the admission sequence.The control group was given Colloidal Bismuth Pectin Capsules,2 grains/time,four times daily.Patients in the observation group were po administered with Weiyanning Granules on the basis of control group,15 g/time,three times daily.Patients in two groups were treated for 4 weeks.The clinical efficacy in two groups was observed,and the symptom scores,ST-36 scale scores,serum inflammatory factor levels,and serological indicators before and after treatment were compared.Results After treatment,the effective rate in the control group was 85.45%,which was significantly lower than 98.18%in the obseration group,and there were differences between two groups(P<0.05).After treatment,the scores of related clinical symptoms in two groups were decreased(P<0.05),and the observation group was the most obvious(P<0.05).After treatment,the SF-36 scores in two groups were significantly improved(P<0.05),and the observation group was the most obvious(P<0.05).After treatment,the serum levels of hs-CRP,IL-8,TNF-α,and SIL-2 R in two groups were significantly improved(P<0.05),and the observation group was the most obvious(P<0.05).After treatment,the serum levels of PGE2,VEGF,GAS,G-17,and SS in two groups were significantly improved(P<0.05),and the observation group was the most obvious(P<0.05).Conclusion Weiyanning Granules combined with Colloidal Bismuth Pectin Capsules can effectively improve the clinical symptoms of patients with chronic atrophic gastritis,reduce the inflammation,and improve the levels of serological indicators.It has good clinical application value.