丝素蛋白水凝胶在骨关节炎中的应用研究

Application of silk fibroin hydrogel in osteoarthritis

随着人口老龄化程度的加剧,骨关节炎患者逐年增多,对人类健康形成了严重威胁。然而,到目前为止,对骨关节炎还缺乏令人满意的临床治疗方法。丝素蛋白是一种天然高分子材料,具有良好的生物相容性、生物可降解性和优良的机械性能等特点,被广泛应用于骨组织工程领域。近年来,随着对丝素蛋白研究的不断深入,越来越多的学者开始尝试以丝素蛋白水凝胶为载体治疗骨关节炎,结果表明,其在骨关节炎的治疗中具有巨大的应用潜能。本文总结了迄今为止关于骨关节炎发病机制、常用药物以及丝素蛋白水凝胶治疗骨关节炎的研究进展,为进一步探索应用丝素蛋白水凝胶治疗骨关节炎奠定了基础。

With the increasing aging of the population,the number of patients with osteoarthritis is increasing year by year,posing a serious threat to human health.However,up to now,there is a lack of satisfactory clinical treatment for osteoarthritis.Silk protein is a natural polymer material with good biocompatibility,biodegradability and excellent mechanical properties,which is widely used in the field of bone tissue engineering.In recent years,with the continuous research on silk fibroin,more and more scholars have started to try to use silk fibroin hydrogel as a carrier for the treatment of osteoarthritis,and the results show that it has great potential for application in the treatment of osteoarthritis.This paper summarizes the research progress so far on the pathogenesis of osteoarthritis,commonly used drugs and the treatment of osteoarthritis with silk fibroin hydrogels,and lays the foundation for further exploration of the application of silk protein hydrogel in the treatment of osteoarthritis.