葶苈大枣泻肺汤加味治疗肺癌合并恶性胸腔积液临床疗效观察

Clinical Observation of Modified Tingli Dazao Xiefei Decoction in the Treatment of Lung Cancer Complicated with Malignant Pleural Effusion

目的:探究葶苈大枣泻肺汤加味治疗肺癌合并恶性胸腔积液的有效性与安全性。方法:采取临床随机对照试验,经随机方式把60名观察对象均等归入观察组、对照组。前者采取葶苈大枣泻肺汤加味口服+贝伐单抗胸腔内注药,后者仅行贝伐单抗胸腔内注药。结果:经研究发现,在治疗肺癌恶性胸腔积液方面,两组具有良好的局部控制率,对比两组显示不存在统计学意义(P>0.05);然而就病人的生活品质与临床表现改善而言,相比对照组,观察组表现出显著优势(P<0.05)。结论:在对肺癌合并恶性胸腔积液进行治疗方面,葶苈大枣泻肺汤加味联合贝伐单抗,能使患者生存品质提升,以及使临床表现有所改善。

Objective:To explore the efficacy and safety of Tingli Dazao Xiefei decoction in the treatment of lung cancer with malignant pleural effusion.Methods:A randomized controlled trial(RCT)was conducted,and 60 subjects were randomly divided into the observation group and the control group.The former was treated with Tingli Dazao Xiefei decoction plus bevacizumab intrapleural injection,while the latter was only treated with bevacizumab intrapleural injection.Results:The study found that in the treatment of lung cancer malignant pleural effusion,the two groups have a good local control rate,compared with the two groups showed no statistical significance(P>0.05);however,in terms of patients’quality of life and clinical performance improvement,compared with the control group,the observation group showed a significant advantage(P<0.05).Conclusion:In the treatment of lung cancer with malignant pleural effusion,Tingli Dazao Xiefei decoction combined with bevacizumab can improve the quality of life of patients and improve the clinical manifestations.