中西医对调节肠道菌群与慢性肾脏病相关性研究进展

Research Progress of Traditional Chinese and Western Medicine on the Regulation of Intestinal Flora in Chronic Kidney Disease

慢性肾脏病患者普遍存在肠道菌群失调,而肠道菌群失调通过蓄积内毒素、降低免疫功能及诱导全身微炎症反应等途径加重肾脏的损伤。大量实验证明中医药通过调节肠道菌群改善患者的代谢功能、免疫功能及微炎症状态,延缓肾脏损伤进展,保护残存肾功能,其治疗符合中医"脾肾学说""伏毒学说"等理论,与肠-肾轴、慢性肾脏病-结肠轴等学说不谋而合。故从中西医病理观、中医药延缓肾衰竭进展机制方面探讨中医药调节肠道菌群在治疗慢性肾脏病中的理论研究。

Intestinal dysbacteriosis is common in patients with chronic kidney disease,which aggravates kidney damage by accumulating endotoxin,reducing immune function and inducing systemic micro inflammation.A large number of experiments have proved that traditional Chinese medicine can improve the metabolic function,immune function and micro inflammatory state of patients by regulating intestinal flora,delay the progress of kidney injury and protect the residual renal function.Its treatment conforms to the theories of“Spleen Kidney Theory”and“latent toxin theory”of traditional Chinese medicine,and coincides with the theories of intestinal kidney axis and chronic kidney disease colon axis.Therefore,this paper discusses the theoretical research of traditional Chinese medicine regulating intestinal flora in the treatment of chronic kidney disease from the aspects of TCM and Western medicine theory of disease and the mechanism of TCM delaying the progression of renal failure.