自拟方地苓消水饮联合芪明颗粒治疗糖尿病性黄斑水肿临床疗效观察

Observation on the Therapeutic Effect of Diling Xiaoshui Yin and Qiming Granule for Eliminating Edema in the Treatment of Diabetic Macular Edema

目的:探索自拟方地苓消水饮联合芪明颗粒治疗气阴两虚型糖尿病性黄斑水肿(DME)的临床疗效。方法:对中医辨证分型为气阴两虚型,符合2型糖尿病,且伴黄斑水肿的60例患者施行不同的治疗方案,观察组、对照组分别入组31例、29例。对照组给予常规用药,观察组在此基础上口服自拟方地苓消水饮加芪明颗粒。疗程均为12周。观察两组用药前后的最佳矫正视力(BCVA)、黄斑中心凹视网膜厚度(CMT)等指标及中医证候积分。结果:两组治疗前后CMT比较具有统计学意义(P<0.05),观察组治疗前后BCVA与中医证候积分比较均具有统计学意义(P<0.05),治疗后组间比较具有统计学意义(P<0.05)。结论:针对气阴两虚型糖尿病性黄斑水肿,自拟方地苓消水饮联合芪明颗粒治疗效果明显,可提高患者中心视力,能改善黄斑中心凹视网膜厚度及全身的证候,具有临床推广价值。

Objective:To observe the clinical effect of Diling Xiaoshui Yin and Qiming Granule in the treatment of Diabetic Macular Edema(DME)due to dual deficiency of qi and yin.Methods:According to the pattern identification in traditional Chinese medicine(TCM),Nonphotorefractive Diabetic Retinopathy(NPDR)with Clinical Significance of Macular Edema(CSME)results from dual deficiency of qi and yin,conforming to type 2 diabetes mellitus.60 patients with above mentioned disease were divided into observation group(n=31)and control group(n=29).The control group was given conventional medication.While based on the same medications in the control group,Diling Xiaoshui Yin and Qiming Granule were given orally in the observation group respectively in the morning,at noon and in the evening.The course of treatment in both groups were 12 weeks.Then observe the Best Corrected Visual Acuity(BCVA),Central Macular Thickness(CMT)and TCM syndrome scores of the two groups before and after medication.Results:CMT comparison between the two groups before and after the treatment was of statistically significant(P<0.05),BCVA and TCM symptom scores of the observation group before and after treatment indicate statistical significance(P<0.05),and after treatment,there were statistically significant differences between the two groups(P<0.05).Conclusion:The therapeutic effect of Diling Xiaoshui Yin and Qiming Granule were significant in the treatment of Diabetic Macular Edema(DME)due to dual deficiency of qi and yin.It can improve the central visual acuity of patients,improve the fovea retinal thickness and systemic syndrome,and has clinical promotion value.