以“调脾法”为基础的治疗方法对慢性肾脏病患者尿β-痕迹蛋白的作用及安全性分析

Effect and Safety Analysis of Treatment Method Based on“Regulating Spleen Method”on Urinaryβ-Trace Protein in Patients with Chronic Kidney Disease

目的:探讨以"调脾法"为基础的治疗方法对慢性肾脏病患者尿β-痕迹蛋白的作用及安全性,为临床诊治提供参考。方法:选择医院2018年5月-2020年2月收治的慢性肾脏病患者118例,随机分为观察组(59例)和对照组(59例)。其中对照组患者给予常规西医治疗,观察组在对照组的基础上联合益肾补脾方治疗。比较两组患者治疗前后肾功能、炎症因子、尿β-痕迹蛋白及中医症候评分变化,并观察两组治疗安全性情况。结果:治疗后,两组患者血清CRP、TNF-α、IL-6、Scr、BUN、β-痕迹蛋白以及中医症候评分均降低,观察组更明显(P<0.05)。治疗前后两组血清ALT、AST水平无明显差异(P>0.05),两组均无明显不良反应。两组治疗后生活质量评分升高,观察组更明显(P<0.05)。结论:益肾补脾方可明显改善慢性肾脏病患者肾功能、微炎症状态,降低β-痕迹蛋白水平,安全性好,效果显著,具有较好的临床应用价值。

Objective:To investigate the effect and safety of urinaryβ-Trace Protein in patients with chronic kidney disease(CKD)based on the therapy of regulating spleen,so as to provide reference for clinical diagnosis and treatment.Methods:118 cases of chronic kidney disease in our hospital from May 2018 to February 2020 were randomly divided into observation group(59 cases)and control group(59 cases).The control group was given conventional western medicine treatment,and the observation group was treated with Yishen Bupi Decoction on the basis of the control group.The changes of renal function,inflammatory factors,urinaryβ-trace protein and TCM syndrome score before and after treatment were compared between the two groups.The differences of safety indexes between the two groups before and after treatment were analyzed.Results:After treatment,the levels of CRP,TNF-α,IL-6,Scr,BUN,β-trace protein and TCM syndrome score of the two groups were significantly decreased,and the observation group was more significant(P<0.05).There was no significant difference in serum ALT and AST levels between the two groups before and after treatment(P>0.05).After treatment,the scores of quality of life in the two groups increased,especially in the observation group(P<0.05).Conclusion:Yishen Bupi recipe can significantly improve the renal function and micro inflammation state of patients with chronic kidney disease,reduce the level ofβ-trace protein,with good safety and significant effect,and has certain clinical application value.