黄精地龙丸治疗脑梗塞康复患者临床疗效观察

Clinical Observation of Huangjing Dilong Wan in the Treatment of Convalescent Patients with Cerebral Infarction

目的:观察黄精地龙丸治疗轻、中度脑梗塞康复患者的临床疗效。方法:采用随机数字表法将87例轻、中度脑梗塞康复患者分为对照组和研究组,对照组42例给予通心络胶囊治疗,研究组45例给予黄精地龙丸治疗,3个疗程后比较两组患者治疗前后各检测指标变化。采用日常生活活动(ADL)量表分析患者治疗前后神经系统症状和体征、肌力、自主生活能力等分值变化,用美国国立卫生院脑卒中神经功能缺损评分量表(NIHSS)检测患者意识思维水平、注意力、语言功能、面肌活动能力、肢体肌力等能力分值变化,以中医辨证量表评估患者肢体麻木、半身不遂、口眼歪斜、舌蹇或不语、胸闷胸痛、神识昏蒙等症状变化,生化法检测患者全血黏度、血浆黏度及血细胞比容等血液流变学变化。结果:两组患者治疗后ADL、NIHSS、中医辨证量表评分值均较治疗前比较差异有统计学意义(P<0.05),但研究组治疗后各值与对照组治疗后各值比较,差异无统计学意义(P>0.05)。研究组治疗总有效率(84.4%)略低于对照组的有效率(85.7%),但差异无统计学意义(P>0.05)。治疗后两组患者的全血黏度、血浆黏度、红细胞压积、纤维蛋白原分别与各组治疗前比较,差异均有统计学意义(P<0.05),治疗后研究组患者血液流变学各指标与对照组比较,差异均无统计学意义(P>0.05)。两组患者均无不良反应发生。结论:黄精地龙丸治疗脑梗塞康复患者疗效较好,可改善患者神经功能症状及日常生活能力,可改善患者脑部供血状况。

Objective:To observe the clinical effect of Huangjing Dilong Wan(HDW)in the treatment of convalescent patients with mild to moderate cerebral infarction.Methods:87 convalescent patients with mild and moderate cerebral infarction were divided into the control group and the research group by random number table method,42 patients in the control group were treated with Tongxinluo capsules,45 patients in the research group were treated with HDW.After 3 courses of treatment,the changes of detection indexes before and after treatment in the two groups were compared,and the changes of detection indexes after treatment in two groups were compared.The activities of daily life(ADL)scale was used to analyze the changes of neurological symptoms and signs,muscle strength and autonomous living ability before and after treatment.The National Institutes of Health Stroke Scale(NIHSS)was used to detect the changes of consciousness and thinking level,attention,language function,facial muscle activity,and limb muscles strength.The TCM syndrome differentiation scale was used to evaluate the changes of the patient’s limb numbness,hemiplegia,mouth and eye deviation,tongue stiffness or silence,chest tightness and chest pain,and mental confusion.The whole blood viscosity,plasma viscosity and hematocrit were detected by biochemical method.Results:The scores of ADL,NIHSS and TCM syndrome differentiation scale in the two groups which after treatment were better than those before treatment,all comparisons have statistically significant differences(P<0.05),but there was no significant difference between the two groups after treatment(P>0.05).The effective rate of the study group(84.4%)was slightly lower than that of the control group(85.7%),but the difference was not statistically significant(P>0.05).After treatment,the whole blood viscosity,plasma viscosity,hematocrit and fibrinogen of the two groups were compared with those before treatment,and the differences were statistically significant(P<0.05).There was no significant difference in hemorheology indexes between the study group and the control group(P>0.05).There were no adverse reaction in the control group and the study group.Conclusion:HDW has good curative effect in the treatment of convalescent patients with cerebral infarction.It can improve the neurological symptoms and activities of daily living,improve the blood supply to the brain and promote the cerebral blood flow.