乌鳢的药理作用研究进展

Research Progress on Pharmacological Activity of Ophiocephalus Argus

乌鳢,也称"黑鱼""乌鱼"等,主要栖息在我国长江流域,北至黑龙江流域。乌鳢体内矿物质含量相对较高,特别是钙、铁、锌等元素,乌鳢提取液中富含不饱和脂肪酸,可促进前列腺素的合成,并影响到伤口愈合中的炎症反应及纤维化过程。乌鳢鱼中所富含的氨基酸如脯氨酸、赖氨酸、天冬氨酸、谷氨酸、甘氨酸也有助于伤口愈合。乌鳢可以清除体内自由基,其提取物治疗的实验动物相比未治疗组表现出关节软组织肿胀明显减少,说明乌鳢鱼具有一定的抗氧化抗炎作用。服用乌鳢提取液的下段,对于剖宫产后女性的子宫伤口恢复效果较为显著。乌鳢不同提取物对心血管系统和神经系统也具有不同的作用,其抗抑郁作用可能与5-HT系统和NA能系统有关。因此,乌鳢具有较大的药用价值和辅助治疗的作用。

Ophiocephalus Argus,also known as"hei yu"and"wu yu",is mainly distributed in the Yangtze River Basin and the north to Heilongjiang.The mineral content of ophiocephalus Argus seems to be relatively high,especially calcium,iron,zinc and other elements.The extract of ophiocephalus Argus is rich in unsaturated fatty acids,which play an significant role in the regulation of prostaglandin synthesis and affect the inflammatory response and fibrosis process in wound healing.The amino acids rich in ophiocephalus Argus,such as proline,lysine,aspartic acid,glutamic acid and glycine,also contribute to wound healing.Compared with the untreated group,the experimental animals treated with the extract showed significantly less swelling of the joint soft tissue,indicating that the snakehead fish has a certain anti-oxidation and anti-inflammatory effect.The effect of uterine wound recovery was significantly enhanced in women who took Post Lower Segment Caesarean Section.Different extracts from ophiocephalus Argus have different effects on cardiovascular system and nervous system,and their antidepressant effects may be related to 5-HT system and noradrenergic system.Therefore,ophiocephalus Argus has a wide range of medicinal value and auxiliary treatment.