含银杏叶提取物成分注射液致38例过敏性休克系统性分析

Systematic Analysis of 38 Cases of Allergic Shock Caused by Three Injections with Ginkgo Biloba Components

目的:通过对3种含有银杏叶提取物成分注射液致过敏性休克不良反应的文献个案报道进行分析,探索其所致严重不良事件的发生规律,为临床合理用药提供参考。方法:以"银杏叶提取物注射液""银杏达莫注射液""舒血宁注射液""过敏性休克"等为检索词,检索出1994-2020年中国期刊全文数据库(CNKI)、万方数据库、维普中文期刊数据、Pubmed数据库中关于以上中药注射剂致过敏性休克的个例文献报道共计28篇,含不良反应病例35例,对其进行统计与分析。结果:过敏性休克事件中40岁以上患者占82.9%,女性多于男性,与原患疾病无显著关系,80%的不良反应事件发生在用药30min内,为速发型不良反应,临床表现为全身性损害。结论:患者既往过敏史、药物成分、制剂工艺、用法用量等因素可能是过敏性休克发生的危险因素。

Objective:Through analysis of literature case reports of anaphylactic shock Caused by Injection with Ginkgo Biloba components,Explore the occurrence of serious adverse reactions,Provide a basis for rational clinical medication.Methods:From 1994 to 2020,a total of 35 cases of adverse reactions of three injections with Ginkgo Biloba components in wanfang database and CNKI and weipu database were retrieved and analyzed with Keywords:"yinxingyetiquwu injection""yinxingdamo injection""shuxuening injection""anaphylactic shock".Results:Among allergic shock events,82.9%of patients were over 40 years old,more women than men,and had no significant relationship with the original disease.80%of adverse reaction events occurred within 30 minutes of use.It was a rapid-onset adverse reaction and the clinical manifestation was systemic damage.Conclusion:The patient’s previous allergy history,drug composition,preparation process,usage and dosage may be risk factors for the occurrence of anaphylactic shock.