大叶紫珠研究进展及应用网络药理学结合分子对接技术预测其治疗出血性疾病作用机制分析

Research progress on chemical constituents and pharmacological effects of Callicarpa macrophylla Vahl and analysis of the mechanism of network pharmacology combined with molecular pair technology to predict and treat hemorrhagic diseases

大叶紫珠化学成分复杂,药理作用广泛,因此本文从大叶紫珠的化学成分、药理作用、质量标准方面进行了综述。由于其止血效果显著,但止血作用机制及止血有效成分尚不明确,因而采用网络药理学结合分子对接技术来预测其治疗出血性疾病的作用机制,发现大叶紫珠的止血成分可能为蛇菰宁、咖啡酸乙酯、松柏醛、莰非醇-3,7,4′-三甲醚、对甲氧基苯甲醛,这些活性成分主要作用于TNF、AKT1、TP53、EGFR、SRC等靶点发挥止血作用。本文旨在进一步为大叶紫珠的开发利用及研究提供参考。

The chemical composition of Viola vulgaris is complex and its pharmacological effects are extensive.Therefore,this paper reviews the chemical composition,pharmacological effects and quality standards of Callicarpa macrophylla Vahl.Its remarkable hemostatic effect,but the mechanism of hemostatic action and effective hemostatic components are unclear.Using network pharmacology combined with molecular docking technology to predict its mechanism of action in the treatment of hemorrhagic diseases.It was found that the hemostatic components of Callicarpa macrophylla Vah may be Balanophonin,Ethy l 3-(3,4-dihydroxypheny l)propionate,2-Propenal,3-(4-hydroxy-3-methoxyphenyl),Kaempferoltrimethylether,beta-Asarone.These active components mainly act on TNF,AKT1,TP53,EGFR,SRC and other targets play a hemostatic effect.The purpose of this paper is to further provide reference for the development,utilization and research of Callicarpa macrophylla Vah.