摘要
报道了光催化苯乙烯与BrCF_(2)CO_(2)Me的2∶2偶联反应,通过原位生成的β-CF_(2)CO_(2)Me取代的苄基自由基完成偶联反应.该反应官能团兼容性好,适用于多种底物类型,可以高产率合成双-二氟乙酸酯己雌酚衍生物.
Photoredox-catalyzed 2∶2 coupling of styrene and BrCF_(2)CO_(2)Me is reported,which undergoes a homo-coupling of in situ generatedβ-CF_(2)CO_(2)Me substituted benzyl radical.The reaction features a wide substrate scope and functional group tolerance to afford bis-difluoroacetylated hexestrol derivatives with high yields.
作者
陈深豪
邹松
席婵娟
Chen Shenhao;Zou Song;Xi Chanjuan(Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology,Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084;State Key Laboratory of Elemento-organic Chemistry,Nankai University,Tianjin 300071)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2023年第3期1157-1167,共11页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21871163,22071134,21911530097)资助项目.
关键词
光催化
自由基自偶联
己雌酚衍生物
photocatalysis
radical homo-coupling
hexestrol derivatives
