导向基辅助的过渡金属催化C(sp^(3))—H键氮宾插入反应研究进展

Recent Progress in Transition Metal Catalyzed C(sp^(3))—H Nitrene Insertion Reactions Assisted by Directing Groups

过渡金属催化C(sp^(3))—H键活化形成碳-氮键的反应一直是具有挑战性且热门的研究领域.过渡金属催化的C(sp^(3))—H胺化策略为形成C—N键提供了更为直接高效的方式.随着碳-氢键活化领域的蓬勃发展,人们发展出了丰富多样的导向基和过渡金属催化体系,为通过内轨机制实现C(sp^(3))—H胺化提供了有效工具.近年来,导向基辅助的C(sp^(3))—H键胺化反应取得了重要进展,许多基于不同过渡金属的催化体系和廉价高效的胺化试剂得以开发.综述了近十年来在导向基团辅助下,过渡金属催化C(sp^(3))—H氮宾插入反应的研究进展.

The transition metal catalyzed activation of C(sp^(3))—H bonds to form carbon-nitrogen bonds has been a challenging and hot research area.The transition metal-catalyzed C(sp^(3))—H amination strategy provides a more direct and efficient way to form C—N bonds.With the vigorous development in the field of C—H bond activation,a variety of directing groups and transition metal catalyst systems have been developed,which provide effective tools for C(sp^(3))—H amination through the inner sphere mechanism.In recent years,important progress has been made in directing group-assisted C(sp^(3))—H bond amination reactions,and many catalyst systems based on different transition metals with cheap and efficient amination reagents have been developed.The research progress of transition metal-catalyzed C(sp^(3))—H nitrene insertion reaction assisted by directing groups in the past decade is reviewed.