摘要
润滑素在肌骨系统各组织如关节软骨、肌腱、滑膜等中广泛表达,其表达与肌骨系统组织结构以及病理状态紧密相关。润滑素在肌骨系统中表现出生物润滑、防止黏连、抑制滑膜细胞增殖和调节炎症等重要功能,对组织损伤修复有重要作用。总结润滑素的表达、调控、结构及其在肌骨系统损伤修复中的作用,为进一步探究润滑素在肌骨系统中的功能和机理以及为肌骨系统损伤的临床治疗提供理论依据。
Lubricin is widely expressed in tissues in the musculoskeletal system,including articulate cartilage,tendon and synovium,which shows a close relationship with the structure and pathology of these tissues.Lubricin plays an important role in lubrication,anti-adhesion,proliferation inhibition and inflammation regulation,which may facilitate the healing of impaired tissues in the musculoskeletal system.This article reviews the research progress on expression and regulation of lubricin as well as its structure and function in wound repair of the musculoskeletal system,so as to provide theoretical evidences for further researches on the role of lubricin in the musculoskeletal system with its related mechanisms and the clinical application of lubricin.
作者
丁忠杰
向燕
罗庆
DING Zhongjie;XIANG Yan;LUO Qing(Key Laboratory of Biorheological Science and Technology,Ministry of Education,College of Bioengineering,Chongqing University,Chongqing 400030,China;Department of Criminal Science and Technology,Chongqing Police College,Chongqing 401331,China)
出处
《医用生物力学》
EI
CAS
CSCD
北大核心
2020年第1期114-119,共6页
Journal of Medical Biomechanics
基金
国家自然科学基金项目(11772073,31700810,11532004).
关键词
润滑素
肌骨系统
组织损伤
组织修复
lubricin
musculoskeletal system
tissue injury
tissue repair
