中成药滋肾育胎丸临床应用新进展

New Progress in Clinical Application of Zishen Yutai Pill

滋肾育胎丸为岭南名优中成药,上市40余年,临床广泛用于先兆流产、复发性流产。通过现代科学技术及前瞻性、大样本、多中心、随机双盲对照临床研究证实了滋肾育胎丸能够提高辅助生殖技术的胚胎种植率、临床妊娠率、活产率,改善卵巢储备功能和子宫内膜容受性,科学地验证了滋肾育胎丸在辅助生殖、卵巢储备功能下降的良好疗效和安全性,拓展了滋肾育胎丸原有的功能主治,创新性地开发了其临床新应用。对标《中成药创新内涵专家共识》,滋肾育胎丸具备中成药创新内涵特征。本文就滋肾育胎丸临床应用研究新进展和循证医学证据进行综述,以期为临床提供有价值的参考。

Zishen Yutai pill is a famous Chinese patent drug in southern China.It has been commercially available for more than 40 years and is widely used in threatened abortion,recurrent spontaneous abortion.Studies proved that Zishen Yutai pill could improve implantation rate,clinical pregnancy rate and live birth rate with the use of modern scientific technology and prospective,large-sample,multicenter,randomized,double-blind,controlled clinical studies.In addition,Zishen Yutai pill could improved ovarian reserve function and endometrial receptivity.A series of studies were conducted,proving its promising efficacy and safety during the use of assisted reproduction and decreased ovarian reserve.The original function of Zishen Yutai pill was expanded and its new clinical application was innovatively developed.On the standard of Expert consensus on innovation connotation of Proprietary Chinese medicine,Zishen Yutai pill has the characteristics of innovation connotation of Chinese patent medicine.This article reviews the new progress of clinical application and evidence-based medical evidence of Zishen Yutai pill,in order to provide valuable references for its clinical application.