长效硝苯地平联合硫酸镁对妊娠期高血压的治疗作用

Objective to compare the therapeutic effects of long-acting nifedipine combined with magnesium sulfate and magnesium sulfate combined with nifedipine on gestational hypertension

目的长效硝苯地平联合硫酸镁对妊娠期高血压的临床疗效。方法对2020年1月~2021年1月间我院收治妊娠期高血压患者235例,分为对照组与实验组,对照组(117例)采用硫酸镁联合短效硝苯地平治疗,实验组(118例)采用长效硝苯地平联合硫酸镁治疗,对比两组治疗效果。结果(1)治疗后实验组24h蛋白尿定量、血细胞压积、血粘度、舒张压、收缩压指标改善优于对照组,具有统计学意义(P<0.05)。(2)实验组不良妊娠结局低于对照组,具有统计学意义(P<0.05)。结论长效硝苯地平联合硫酸镁治疗妊娠期高血压,能有效降低患者血压值,能有效改善患者血液动力学,提高妊娠结局。

Objective:To compare the clinical efficacy of long-acting nifedipine combined with magnesium sulfate and magnesium sulfate combined with nifedipine in the treatment of gestational hypertension.Methods:from January 2020 to January 2021,235 patients with gestational hypertension were randomly divided into control group and experimental group.117 patients in the control group were treated with magnesium sulfate combined with short acting nifedipine,while 118 patients in the experimental group were treated with long acting nifedipine combined with magnesium sulfate.Results:(1)before treatment,there was no significant difference in 24-hour proteinuria,hematocrit,blood viscosity,diastolic blood pressure and systolic blood pressure between the two groups(P>0.05).After treatment,the above indexes in the experimental group were better than those in the control group,with statistical significance(P<0.05).(2)The dystocia,cesarean section,fetal distress,placental abruption,postpartum hemorrhage and fetal mortality of the experimental group were lower than those of the control group,with statistical significance(P<0.05).Conclusion:Long-acting nifedipine combined with magnesium sulfate in the treatment of hypertension during pregnancy can effectively reduce the patient’s blood pressure,effectively improve the patient’s hemodynamics,and improve pregnancy outcome.