红细胞微粒与动脉粥样硬化相关性研究进展

Research progress on correlation between erythrocyte-derived microparticles and atherosclerosis

动脉粥样硬化是冠心病、外周动脉硬化闭塞症等多种心血管疾病的共同病理基础,其发生、发展的分子机制十分复杂,斑块内微血栓形成、局部炎症反应、免疫反应等多种因素共同参与并相互作用。红细胞微粒特指由红细胞产生的含膜小泡,具有促进凝血、参与炎症反应、调节血管内皮功能等多种生物活性。循环的红细胞微粒可能包含潜在的有价值的生物信息,可用于开发心血管疾病的特异性生物标志物,并可以作为治疗使用的载体。因此,认识红细胞微粒在动脉粥样硬化中的作用至关重要,这有助于从分子水平了解动脉粥样硬化的机制,或可为心血管疾病提供新的诊断和治疗靶点。

Atherosclerosis is the common pathological basis of coronary heart disease,peripheral arteriosclerosis obliterans and other cardiovascular diseases,its molecular mechanism of occurrence and development is very complex,and many factors such as microthrombosis in plaque,local inflammation and immune response participate in this process and interact with each other.Erythrocyte-derived microparticles are membrane containing vesicles produced by red blood cells,which have many biological activities,such as promoting blood coagulation,participating in inflammatory reaction,regulating vascular endothelial function and so on.Circulating erythrocyte-derived microparticles may contain potentially valuable biological information,which can be used to develop specific biomarkers for cardiovascular disease,and can be used as a carrier for treatment.Therefore,it is very important to understand the role of erythrocyte-derived microparticles in atherosclerosis,which is helpful to understand the mechanism of atherosclerosis at the molecular level,or to provide new diagnostic and therapeutic targets for cardiovascular diseases.