姜黄素治疗非酒精性脂肪性肝病的研究进展

Research progress of curcumin in the treatment of non-alcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是慢性肝损伤的原因之一,发病机制复杂。胰岛素抵抗、氧化应激、肠-肝轴和线粒体功能障碍等共同导致NAFLD的发生、发展。姜黄素是一种天然多酚类物质,是治疗NAFLD的潜在药物,并已广泛开展了实验研究。本研究对NAFLD的发病机制及姜黄素对NAFLD的治疗作用进行综述。

Non-alcoholic fatty liver disease(NAFLD)is one of causes of chronic liver injury,and the pathogenesis is complex.Insulin resistance,oxidative stress,intestinal-hepatic axis and mitochondrial dysfunction lead to the occurrence and development of NAFLD.Curcumin,a natural polyphenol,is a potential drug for the treatment of NAFLD,and has been widely studied in experimental researches.This study reviewed pathogenesis of NAFLD and the therapeutic effect of curcumin on NAFLD.