健康体检人群颈动脉斑块形成与幽门螺杆菌感染的相关性研究

Correlation between formation of carotid atherosclerotic plaque and Helicobacter pylori infection in people with health examination

目的探讨健康体检人群颈动脉斑块形成与幽门螺杆菌(Hp)感染的相关性。方法将286例颈动脉斑块人群作为颈动脉斑块组,314例非颈动脉斑块人群作为对照组。设计问卷收集人口学资料和生活行为,采用多因素Logistic回归分析颈动脉斑块与Hp感染的相关性。结果颈动脉斑块组Hp感染率高于对照组,差异有统计学意义(P=0.003)。单因素分析显示,2组BMI、腰围、吸烟史、高血压、高密度脂蛋白胆固醇(HDL-C)、Hp感染及空腹血糖差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,颈动脉斑块形成与体检人群的BMI、吸烟史、高血压及Hp阳性有关,Hp阳性可作为颈动脉斑块形成的独立危险因素。结论健康体检人群颈动脉斑块Hp感染率较高,Hp感染人群应重视颈动脉斑块的预防。

Objective To explore the correlation between formation of carotid atherosclerotic plaque and Helicobacter pylori(Hp)infection in people with health examination.Methods Totally286 patients with carotid plaque were selected as carotid plaque group and 314 patients without carotid plaque were selected as control group.A questionnaire was designed to collect demographic data and life behaviors.Multivariate Logistic regression was used to analyze the correlation between carotid plaque and Hp infection.Results The Hp infection rate of the carotid plaque group was significantly higher than that of the control group(P=0.003).Univariate analysis showed that there were significant differences in body mass index(BMI),waist circumference,smoking history,high density lipoprotein cholesterol(HDL-C),Hp infection and fasting blood glucose between the two groups(P<0.05).Multivariate Logistic regression analysis showed that the formation of carotid plaque was related to BMI,smoking history,hypertension and positive-Hp,and positive-Hp could be regarded as an independent risk factor for the formation of carotid plaque.Conclusion The Hp infection rate of carotid plaque in healthy people is relatively high,and more attention should be paid in the prevention of carotid plaque in Hp infected people.