原发性高血压患者血清salusin-β水平与颈动脉病变关系

Relationship between level of serum salusin-β and carotid artery disease in patients with essential hypertension

目的探究原发性高血压患者外周血中salusin-β水平与颈动脉病变关系。方法选取营口市中心医院2017年8月至2019年5月收治的140例原发性高血压患者作为观察组,用彩色多普勒超声观察颈动脉内膜厚度,分为颈动脉内膜正常组(55例)、颈动脉斑块组(35例)以及颈动脉内膜增厚组(50例)。选取同期在我院进行健康体检者40例作为对照组。检测患者外周血中salusin-β水平,比较各组salusin-β水平,并分析salusin-β与颈动脉斑块的关系。结果观察组外周血中salusin-β水平[(4.35±1.25)nmol/L]高于对照组[(3.37±0.91)nmol/L],差异有统计学意义(t=4.617,P<0.05)。颈动脉斑块组salusin-β水平[(4.88±1.36)nmol/L]高于颈动脉内膜正常组[(3.65±1.02)nmol/L]和颈动脉内膜增厚组[(4.23±1.18)nmol/L],差异有统计学意义(t=4.887、2.352,P<0.05)。观察组患者中,颈动脉斑块组高血压病程、高血脂、入院收缩压、salusin-β水平以及胆固醇水平高于无颈动脉斑块患者,差异有统计学意义(χ2/t=4.814、15.041、4.684、3.824、4.684,P<0.05)。多因素回归分析发现,合并高血脂、高血压病程、salusin-β是原发性高血压患者颈动脉斑块的独立危险因素(OR=1.102、1.312、1.671,P<0.05)。在高血压合并颈动脉斑块患者中,salusin-β水平与胆固醇、收缩压、舒张压呈正相关(r=3.651、3.251、3.013,P<0.05)。结论原发性高血压患者外周血salusin-β水平与颈动脉病变严重程度密切相关,salusin-β水平可能成为原发性高血压颈动脉斑块的有效生物学标记物。

Objective To investigate the relationship between level of salusin-βand carotid artery disease in peripheral blood of patients with essential hypertension.Methods A total of 140 patients with essential hypertension admitted to Yingkou central hospital from August 2017 to May 2019 were selected as the observation group,forty healthy people in the hospital in the same term were selected as the control group.The level of salusin-βin peripheral blood was measured.The carotid intima thickness was observed by color doppler ultrasound.The patients were divided into the normal carotid intima group(55 cases),carotid plaque group(35 cases),and carotid intima thickening group(50 cases).The levels of salusin-βwere compared and the relationship between salusin-βand carotid plaques was observed.Results The level of salusin-βin the peripheral blood of the observation group[(4.35±1.25)nmol/L]was higher than that of the control group[(3.37±0.91)nmol/L],and the difference was statistically significant(t=4.617,P<0.05).The level of salusin-βin the carotid plaque group[(4.88±1.36)nmol/L]was higher than that in the normal carotid intima group[(3.65±1.02)nmol/L]and the carotid intima thickening group[(4.23±1.18)nmol/L],the differences were statistically significant(t=4.887,2.352,P<0.05).Among the observation group,the course of hypertension,hyperlipidemia,admission systolic blood pressure,salusin-βlevel and cholesterol level in the carotid plaque group were higher than those patients without carotid plaque,and the difference was statistically significant(χ2/t=4.814,15.041,4.684,3.824,4.684,P<0.05).Multivariate regression analysis found that hyperlipidemia,hypertension,and salusin-βwere independent risk factors for carotid plaque in patients with essential hypertension(OR=1.102,1.312,1.671,P<0.05).In patients with hypertension and carotid plaque,salusin-βlevel was positively correlated with cholesterol,systolic blood pressure and diastolic blood pressure(r=3.651,3.251,3.013,P<0.05).Conclusion The level of salusin-βin peripheral blood of patients with essential hypertension is closely related to the severity of carotid artery disease.The level of salusin-βmay be an effective biomarker for carotid plaque in primary hypertension.