法舒地尔联合银杏内酯注射液治疗缺血性脑卒中的效果及预后

Analysis about the effect and prognosis of fasudil combined with ginkgolide injection in the treatment of ischemic stroke

目的探讨法舒地尔联合银杏内酯注射液治疗缺血性脑卒中的效果及预后。方法选择92例某医院神经内科收治的缺血性脑卒中患者为研究对象,采集时间2018年12月22日/2020年2月11日,根据患者治疗方式分两组,每组46例,银杏内酯注射液参照组(U组),银杏内酯注射液联合法舒地尔联合治疗研究组(S组),观察两组患者治疗效果、各项功能预后情况、后遗症及不良预后情况。结果治疗前:S组、U组卒中量表(NIHSS)评分、神经功能(Barthel)指数、患者生活能力(m RS)评分无明显差异(P>0.05,t=0.773、7.385、16.184);治疗3个月后:S组NIHSS[(9.01±0.11)分]、Barthel[(92.22±1.03)分]、m RS[(1.20±0.06)分]、治疗有效率95.65%、复发率4.35%,U组NIHSS[(11.54±0.12)分]、Barthel[(90.31±1.42)分]、mRS[(1.42±0.07)分]、治疗有效率76.09%、复发率10.87%,数据比对S组复发率略低于U组,但无统计学意义(P>0.05),除此外S组更优,P<0.05,有统计学意义。治疗6个月后,S组、U组均无死亡患者。治疗6个月后,S组后遗症发生率7.14%、U组后遗症发生率28.57%,S组低于U组,P<0.05,有统计学意义。结论在在治疗缺血性脑卒中时,银杏内酯注射液联合法舒地尔的联合治疗手段,在一定程度上可以改善患者预后、增强治疗效果。

Objective To investigate the effect and prognosis of Fasudil combined with Ginkgolide injection in the treatment of ischemic stroke.Methods Ninety-two patients with ischemic stroke admitted to the department of Neurology of a hospital from December22,2018 to February 11,2020 were selected as the research objects.According to different treatment methods,they were divided into two groups:Ginkgo biloba Lactone injection group(U group)and Ginkgolide injection combined with Fasudil group(S group),with 46 cases in each group.Treatment effect,prognosis of various functionsand sequelaebetween two groups were compared.Results Stroke scale(NIHSS)score,neurological function(Barthel)index,and patient living ability(mRS)score between two groups before treatmenthad no significant differences(P>0.05,t=0.773,7.385,16.184).After three months of treatment,NIHSS score in the S group was[(9.01±0.11)points],Barthel score in the S group was[(92.22±1.03)points],mRS score in the S group was[(1.20±0.06)points],treatment effective rate in the S group was 95.65%,and the recurrence rate was 4.35%.In the U group,NIHSS score was[(11.54±0.12)points],Barthel score was[(90.31±1.42)points],mRS score was[(1.42±0.07)points],treatment effective rate was 76.09%,and recurrence rate was 10.87%.All above data showed that the recurrence rate of S group was slightly lower than that of U group,but the difference was not statistically significant(P>0.05),while other data in S group was better than those in U group(P<0.05).After 6 months of treatment,No cases died in both groups.After 6 months of treatment,the incidence of sequelae in S group was 7.14%and it was lower than that in group U which was 28.57%(P<0.05).Conclusion In the treatment of ischemic stroke,combined Ginkgolide injection with Fasudil can improve the prognosis of patients and enhance the treatment effect to a certain extent.