FGF-21联合sST2对老年持续性心房颤动患者发生血栓事件的效能预测

Efficacy of FGF-21 combined with sST2 in predicting thrombotic events in elderly patients with persistent atrial fibrillation

目的分析血清人类成纤维细胞生长因子21(FGF-21)联合可溶性基质裂解素2(sST2)对老年持续性心房颤动患者发生血栓事件的预测效能。方法选择本院自2019年3月-2021年3月接诊108例老年持续性心房颤动患者为观察组,另选同期的108例健康体检者作为对照组,比较两组血清FGF-21、sST2水平。根据观察组患者是否发生血栓事件,分为血栓事件组和非血栓事件组,使用单因素分析和多因素Logistic回归分析血栓事件的独立预测因素,通过受试者工作特征(ROC)曲线下面积(AUC)评价血清FGF-21联合sST2对血栓事件的预测效能。结果观察组血清FGF-21、sST2水平明显高于对照组,差异均有统计学意义(P<0.05);血栓事件组血清FGF-21、sST2水平明显高于非血栓事件组,差异均有统计学意义(P<0.05);经多因素Logistic回归分析,HCY、CHA2DS2-VASc评分、FGF-21、sST2均是老年持续性心房颤动患者发生血栓事件的独立预测因素(P<0.05);经ROC曲线分析,血清FGF-21联合sST2预测老年持续性心房颤动患者发生血栓事件的AUC(0.910),明显大于HCY(0.625)和CHA2DS2-VASc评分(0.755),差异均有统计学意义(P<0.05)。结论老年持续性心房颤动患者血清FGF-21、sST2水平均明显升高,两者联合预测血栓事件的效能较好,值得进一步研究应用。

Objective To analyze the efficacy of serum human fibroblast growth factor 2(FGF-21)combined with soluble matrix lysin 2(sST2)inpredicting thrombotic events in elderly patients with persistent atrial fibrillation.Methods A total of 108 elderly patients with persistent atrial fibrillation admitted to our hospital from March 2019 to March 2021 were selected as the observation group,and 108healthy subjects during the same period were selected as the control group.The levels of serum FGF-21 and sST2 between two groups were compared.Patients in the observation group were divided into thrombotic event group and non-thrombotic event group according to whether thrombotic event occurred or not.Univariate analysis and multivariate Logistic regression were used to analyze independent predictors of thrombotic event,and the predictive efficacy of serum FGF-21 combined with sST2 on thrombotic event was evaluated by area under receiver operating characteristic(ROC)curve(AUC).Results The levels of serum FGF-21 and sST2 in observation group are significantly higher than those in control group,with statistical significance(P<0.05).The serum levels of FGF-21 and sST2 in the thrombus event group are significantly higher than those in the non-thrombus event group,and the differences are statistically significant(P<0.05).Multiple Logistic regression analysis shows that Hcy,CHA2DS2-VASc score,FGF-21 and SST2 were independent predictors of thrombotic events in elderly patients with persistent atrial fibrillation(P<0.05).According to ROC curve analysis,AUC of serum FGF-21 combined with sST2 was 0.910,which was significantly higher than that data for Hcy(0.625)and that for CHA2DS2-VASc score(0.755),and the differences were statistically significant(P<0.05).Conclusion The serum levels of FGF-21 and sST2 are significantly increased in elderly patients with persistent atrial fibrillation,the combination of FGF-21 and sST2 is effective in predicting thrombotic events,which is worthy of further study and application.