rTMS在儿童青少年双相抑郁患者中疗效观察

Efficacy of rTMS in children and adolescents with bipolar depression

目的 探讨重复颅磁刺激治疗(r TMS)对儿童青少年双相抑郁患者的疗效。方法 选择2020年12月-2021年12月在新疆维吾尔自治区人民医院,临床心理科期间住院并愿意接受研究的,67例儿童青少年双相抑郁患者,以单双号随机分为研究组和对照组。两组均给予常规方案药物治疗,研究组在常规药物治疗基础上联合重复经颅磁刺激治疗,对照组在常规治疗的基础上给予伪刺激治疗。分别于治疗前、治疗2周后、治疗4周后,采用HAMD和SIOSS量表评估疗效,不良反应使用TESS量表评估。结果 (1)治疗前研究组与对照组HAMD、SIOSS评分没有统计学差异(P>0.05),治疗2周后,4周后两组的评分均降低,研究组降低更显著(HAMD:t_(2周)=-2.808,t_(4周)=-3.016;P<0.05;SIOSS:t_(2周)=-3.340,t_(4周)=-3.548;P<0.05)。(2)治疗4周后研究组有效率高于对照组,两组比较差异,具有统计学意义。HAMD(88.7%vs70.7%;χ^(2)=3.992,P<0.05);SIOSS:(81.7%vs.73.7%;χ^(2)=5.933,P<0.05)。结论 与药物治疗相结合的r TMS,对儿童和青少年中双相抑郁患者治疗有明显效果。

Objective To investigate the effect of repeated transcranial magnetic stimulation(rTMS) on bipolar depression in children and adolescents.Methods A total of 67 children and adolescents with bipolar depression who were hospitalized in the department of clinical Psychology in Xinjiang Uygur Autonomous Region People’s Hospital from December 2020 to December 2021 and were willing to accept the study were included in this study.They were randomly divided into the study group and the control group with odd and even numbers.Both groups were given conventional drug therapy,the research group was given repetitive Transcranial magnetic stimulation(TMS) on the basis of conventional drug therapy,and the control group was given pseudo-stimulation on the basis of conventional treatment.HAMD and SIOSS scales were used to evaluate efficacy before treatment,2 weeks after treatment,and 4 weeks after treatment,respectively.TESS scale was used to evaluate adverse reactions.Results(1) Before treatment,there were no statistically significant differences in HAMD and SIOSS scores between the study group and the control group(P>0.05).After 2 weeks of treatment,4 weeks after treatment,the scores of both groups decreased,and the decrease was more significant in the study group(HAMD:Week T_(2)=-2.808,week T_(4)=-3.016;P<0.05;SIOSS:T_(2 week)=-3.340,T_(4 week)=-3.548;P<0.05).(2) After 4 weeks of treatment,the effective rate of the study group was higher than that of the control group,and the difference between the two groups was statistically significant.HAMD(88.7% vs70.7%;χ^(2)=3.992,P<0.05);SIOSS:(81.7% vs.73.7%;χ^(2)=5.933,P<0.05).Conclusion rTMS combined with drug therapy has a significant effect on the treatment of bipolar depression in children and adolescents.