低获卵周期患者不同受精方式的临床分析

Clinical analysis of different fertilization methods in patients with low oocyte retrieval cycle

目的比较低获卵周期患者常规体外受精(IVF)和卵胞浆内单精子显微注射(ICSI)受精后的胚胎及妊娠结局。方法回顾分析拮抗剂方案促排后低获卵数周期的非男性因素不孕症患者,分别接受IVF(276例)和ICSI(97例)方式受精,比较两组的临床资料、胚胎情况和妊娠情况。结果两组的一般资料及治疗相关临床资料均无统计学意义(P>0.05)。ICSI组的2PN受精率、优质胚胎率、临床妊娠率、流产率均高于常规IVF组,但差异均无统计学意义(P>0.05)。结论ICSI的使用应限于男性因素不孕或有完全受精因素不孕史的患者,需要根据患者的实际情况和男方精子质量等选择合适的方式进行助孕,尽可能的避免无指征的非男性因素ICSI受精。

Objective To compare the embryo and pregnancy outcomes after conventional in vitro fertilization(IVF)and intracytoplasmic sperm injection(ICSI)in patients with low oocyte cycle.Methods Non-male infertility patients with fewer oocytes retrieved cycles after antagonist ovulation induction regiments were retrospectively analyzed.They were fertilized by IVF(n=276)and ICSI(n=97),respectively.The clinical data,embryo and pregnancy of the two groups were compared.Results There was no statistical significance in the general data and treatment-related clinical data of the two groups(P>0.05).The 2PN fertilization rate,good-quality embryo rate,clinical pregnancy rate and abortion rate in ICSI group were higher than those in conventional IVF group,but the difference was not statistically significant(P>0.05).Conclusion The use of ICSI should be limited to patients with male infertility or a history of infertility due to complete fertilization.According to the actual situation of the patient and the sperm quality of the man,choose an appropriate way to assist pregnancy.Non male factors without indications should be avoided for ICSI fertilization.