血清胱抑素C和β2-微球蛋白联合检测在糖尿病肾病早期诊断的应用价值分析

Analysis of the application value of combined detection of serum cystatin C and β2-microglobulin in the early diagnosis of diabetic nephropathy

目的探讨血清胱抑素C和β2-微球蛋白检测在联合早期诊断糖尿病肾病的应用价值分析。方法研究对象选取东莞市长安镇长安医院2017年8月到2019年9月间收治的糖尿病肾病患者81例,作为研究组;同期选择健康体检者70例,作为对照组。采用免疫比浊法,检测两组研究对象的血清胱抑素C、β2-微球蛋白、肌酐及尿素水平,同时比较两组差异。结果研究组糖尿病肾病患者血清胱抑素、β2-微球蛋白、肌酐、尿素均高于对照组,差异均有显著统计学意义(P<0.01)。不同分期患者之间血清胱抑素C、β2-微球蛋白水平从I期到IV期呈递增趋势,与I期比较,Ⅱ期、Ⅲ期和Ⅳ期差异均有统计学意义(P<0.01)。结论联合血清胱抑素C和β2-微球蛋白检测对于早期诊断糖尿病肾病具有重要应用价值,同时均为早期敏感指标,值得在临床推广。

Objective To investigate the application value of combined detection of serum cystatin C andβ2-microglobulin in the early diagnosis of diabetic nephropathy.Methods 81 patients with diabetic nephropathy admitted in the Chang’an hospital of Chang’an Town in Dongguan City from August 2017 to September 2019 were selected as the research object,as the study group;70 subjects with health examination were selected as the control group in the same period.The immunoturbidimetric method was used to detect the serum cystatin C,β2-microglobulin,creatinine and urea levels of the two groups of subjects,and compared the differences between the two groups at the same time.Results Serum cystatin,β2-microglobulin,creatinine,and urea levels of the study group of diabetic nephropathy patients were higher than those of the control group,and the difference was statistically significant(P<0.01).The levels of serum cystatin C andβ2-microglobulin among patients of different stages showed an increasing trend from stage I to stage IV.Compared with stageⅠ,there were statistically significant differences in stageⅡ,stageⅢand stageⅣ(P<0.01).Conclusion The combination of serum cystatin C andβ2-microglobulin has a certain diagnostic value for early diagnosis of diabetic nephropathy.Both of them are early sensitive indicators,and worthy of clinical promotion.