高攻击风险男性精神分裂症患者事件相关电位研究

Event-related potential studies in male patients with violent schizophrenia

目的探讨男性高攻击风险精神分裂症患者事件相关电位的特征。方法将入院一周之内男性高攻击风险精神分裂症患者100例作为观察组,将男性无攻击风险精神分裂症患者100例作为对照组,将观察组和对照组分别进行事件相关电位的检测,根据检测结果判断男性高攻击风险的精神分裂症患者的医用事件相关电位的特征。结果2组间P300潜伏期差异无统计学意义(P>0.05);观察组P300波幅低于对照组,差异有统计学意义(P<0.05);2组间P50观察组比对照组有更大的S2/S1值,结果有统计学差异。结论高攻击风险的男性精神分裂症患者与无攻击风险的男性精神分裂症患者在事件相关电位存在差异性。

Objective To observe the characteristics of event-related potentials of male patients undergoing schizophrenia with violent behavior.Methods 100 patients with violence within one week of admission were used as observation group and 100 patients with no violence as control group.Event-related potentials were measured in observation group and control group respectively.The characteristics of medical event-related potentials in patients with schizophrenia with violent behavior were judged according to the results.Results There was no significant difference in the latency of P300 between the two groups(P>0.05),but the amplitude of P300 in the observation group was lower than that in the control group(P<0.05),and the S2/S1 value in the P50 observation group was higher than that in the control group.Conclusion That patients with schizophrenia with violent behavior have different event-related potentials from those with non-violent schizophrenia.