C1q阳性肿瘤相关巨噬细胞在免疫治疗抵抗中的研究进展

Advances on Relating C1q-Positive Tumor-Associated Macrophages to Immunotherapy Resistance

补体C1q与肿瘤相关巨噬细胞(TAMs)对肿瘤的发生起重要作用。近年研究显示,C1q表达阳性的TAMs(C1q^(+)TAMs)与多种恶性肿瘤进展和免疫治疗抵抗密切相关,可作为新的预后、转移和复发的预测分子标志物,并有望成为抗肿瘤治疗的新靶点。全文总结了C1q、TAMs、C1q^(+)TAMs介导免疫治疗抵抗的可能机制,并对三者间的相互关系进行了探讨。

Complement C1q and tumor-associated macrophages(TAMs)are involved in the tumorigenesis of malignant tumors.Recent studies have revealed that C1q-positive TAMs(C1q^(+)TAMs)are closely related to the progression and immunotherapy resistance of various malignant tumors,indicating that C1q^(+)TAMs might be used as new molecular markers for predicting prognosis,metastasis,and recurrence of malignant tumors,and potential treatment targets.This review summarizes the mechanisms of C1q,TAMs,and C1q^(+)TAMs mediated resistance of tumor immunotherapy.