摘要
[目的]探讨体素内不相干运动(intravoxel incoherent motion,IVIM)扩散加权成像(diffusion-weighted imaging,DWI)参数与早期宫颈癌肿瘤基质比(TSR)的相关性。[方法]2021年1月1日至2021年12月1日期间选择77例早期宫颈癌患者纳入研究。患者均接受IVIM-DWI成像,并测量D、D*和f值参数。根据TSR将肿瘤分为基质丰富组和基质贫乏组,对两组的IVIM参数进行比较。采用多元回归分析IVIM参数与TSR之间的关系。[结果]基质丰富肿瘤的D值和f值显著性低于基质贫乏肿瘤(P=0.018、0.015)。D值与TSR呈密切负相关(r=-0.642,P=0.015),f值与TSR呈中度负相关(r=-0.503,P=0.028)。D值和f值在区分基质丰富和基质贫乏肿瘤的ROC曲线下面积分别为0.834(95%CI:0.617~0.906)和0.677(95%CI:0.576~0.794)。多元回归分析显示,肿瘤大小(P=0.007)、TSR(P=0.008)、组织学分级(P=0.012)和组织类型(P=0.031)与D值相关。肿瘤大小(P=0.011)、TSR(P=0.021)和组织类型(P=0.037)与f值相关。[结论]IVIM-DWI获得的D值和f值可以反映早期宫颈癌的TSR特征。
[Objective]To investigate the association of parameters derived from intravoxel incoherent motion(IVIM)diffusion-weighted imaging(DWI)with tumor stroma ratio(TSR)in early-stage cervical cancer.[Methods]Between January 2021 and December 2021,77 patients with earlystage cervical cancer were enrolled in this study.All patients underwent IVIM-DWI imaging,and D,D*,and f-values were measured.Tumors were divided into stromal-rich and stromal-poor group according to TSR,and the IVIM parameters of the two groups were compared.Multivariate regression was used to analyze the relationship between IVIM parameters and TSR.[Results]Stoma-rich tumor had significantly lower D and f value than stroma-poor tumor(P=0.018,0.015).The D value and f value were negatively correlated with TSR(r=-0.642,P=0.015;r=-0.503,P=0.028).The areas under the ROC curve(AUC)of D and f value for distinguishing stromal-rich and stromal-poor tumor were 0.834(95%CI:0.617~0.906)and 0.677(95%CI:0.576~0.794),respectively.Multiple linear regression analysis showed tumor size(P=0.007),TSR(P=0.008),histological grade(P=0.012)and histological type(P=0.031)were independently associated with D value,tumor size(P=0.011),TSR(P=0.021)and histological type(P=0.037)were independently associated with f-value.[Conclusion]D value and f value obtained from IVIM-DWI can reflect the TSR characteristics of early cervical cancer.
作者
何子福
贾方
HE Zi-fu;JIA Fang(The First Affiliated Hospital of Air Force Military Medical University,Xi’an 710032,China)
出处
《肿瘤学杂志》
CAS
2022年第12期1031-1035,共5页
Journal of Chinese Oncology
基金
陕西省自然科学基金(2020-Z-194)
关键词
体素内不相干运动
扩散加权成像
宫颈癌
肿瘤基质比
intravoxel incoherent motion
diffusion weighted imaging
cervical cancer
tumor stroma ratio