孕烷X受体在肾脏疾病中的研究进展

Research Progress of Pregnane X Receptor in Kidney Disease

核受体是一类在机体内广泛分布的转录因子,在人体生理、病理过程中发挥重要作用。孕烷X受体(pregnaneX receptor,PXR)为核受体家族成员之一,参与机体物质代谢,尤其在药物代谢中起关键作用。肾脏是药物代谢的主要器官之一,PXR参与肾脏药物代谢、转运等多种调节并参与多种肾脏疾病的病理生理过程。近年来多项研究关注PXR及其调控作用对肾脏及肾脏疾病的影响。本文将从PXR在肾脏与药物代谢和转运相关酶的相互作用以及PXR在肾脏疾病中的作用等方面进行综述。

Nuclear receptors are a group of transcription factors that widely distributed in the body and play an important role in both physiological and pathological processes.Pregnane X receptor(PXR)is a member of the nuclear receptor family,which is mainly involved in various biological activities,especially in drug metabolism.Kidney is one of the main organs that take part in the regulation of drug metabolism.PXR is involved in various regulation such as renal drug metabolism and transport,and is involved in the pathophysiological process of various kidney diseases.In recent years,researchers have focused on the effects of PXR and its regulatory functions in kidney and renal diseases.This review mainly discusses the role of PXR on renal physiology,the interaction of PXR and the drug metabolic enzymes and its functions in pathological process in renal diseases.