混合加权法结合响应面试验优化视力舒颗粒煎煮工艺

Optimization of the Decocting Process of Shilishu Granules by Mixed Weighting Method and Response Surface Methodology

目的优选视力舒颗粒最佳煎煮工艺。方法以金丝桃苷、橙皮苷、葛根素、总多糖得率、干膏得率为考察指标,采用层次分析法(analytic hierarchy process,AHP),基于指标相关性的权重赋权法(criteria importance through inter-criteria correlation,CRITIC)、AHP-CRITIC混合加权法,分别对指标测得数据进行权重分配并综合评分,比较单一赋权法和混合加权法评分结果,以综合评分为响应值进行Box-Behnken响应面试验优化煎煮工艺,并加以验证。结果AHP-CRITIC混合加权较单一赋权法更科学、合理、全面,视力舒颗粒最优煎煮工艺为加11倍量水,煎煮3次,每次80 min。结论AHP-CRITIC法可用于视力舒颗粒煎煮工艺多指标权重的确定,经过验证试验证实了优选出的煎煮工艺稳定可行,可用于工业化大生产。

OBJECTIVE To optimize the best decocting process of Shilishu granules.METHODS Taking hypericin,hesperidin,puerarin,total polysaccharide yield and dry extract yield as the indexes,the weight distribution and comprehensive score of the measured data were carried out by analytic hierarchy process(AHP),criteria importance through inter-criteria correlation(CRITIC)and AHP-CRITIC mixed weighting method.The results of single weighting method and mixed weighting method were compared,and the Box-Behnken response surface test was carried out with the comprehensive score as the response value to optimize the decoction process and verify it.RESULTS The AHP-CRITIC mixed weighting method was more scientific,reasonable and comprehensive than the single weighting method.The optimal decocting process was to add 11 times the amount of water and decoct 3 times for 80 min each time.CONCLUSION AHP-CRITIC method can be used to determine the weight of multiple indexes in the decocting process of Shilishu granules.The validation test shows that the optimized decocting process is stable and feasible,and can be used in industrial production.