摘要
血栓是缺血性心脑血管疾病的主要杀手,血小板聚集在血栓形成过程中发挥着重要的作用。抗血小板聚集在血栓性疾病的治疗中无可替代。cGMP对血小板功能的调节起到非常重要的作用,且主要通过eNOS-NO-cGMP-PKG通路进行调节。本综述主要阐明cGMP在血小板聚集中的作用和机制。
Thrombosis is the main killer of ischemic cardiovascular and cerebrovascular diseases.Platelet aggregation plays an important role in the process of thrombosis.Anti-platelet aggregation is irreplaceable in the treatment of thrombotic diseases.cGMP plays a very important role in the regulation of platelet function;and its role is mainly through the eNOS-NO-cGMP-PKG pathway.This review mainly clarifies the effect and mechanism of cGMP on platelet aggregation.
作者
李青宴
黄艳华
沈磊
LI Qingyan;HUANG Yanhua;SHEN Lei(College of Pharmacy,Dali University,Dali 671000,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2021年第23期3045-3049,共5页
Chinese Journal of Modern Applied Pharmacy
基金
云南省科技厅地方本科高校基础研究项目(2018FH001-096)
关键词
血小板聚集
环磷酸鸟苷
内皮型一氧化氮合酶
一氧化氮
cGMP依赖的蛋白激酶G
信号通路
platelet aggregation
guanosine 3’,5’-cyclic monophosphate(cGMP)
endothelial nitric oxide synthase(eNOS)
NO
cGMP-dependent kinase(PKG)
signaling pathway
