抑郁症患者唾液皮质醇与龋病的相关性研究

Correlation between saliva cortisol and caries in depressed patients

目的探讨抑郁症患者唾液皮质醇浓度与龋病的相关性。方法收集已确诊抑郁症患者(实验组)及健康体检人群(对照组)晨起8~10时静息状态下自然分泌的混合唾液3ml,采用酶联免疫吸附测定法(enzyme linked immunosorbent assay,ELISA)测算两组人群唾液中皮质醇浓度,通过量表调查的形式评估其精神状态,并进行一般口腔检查,记录数据并统计分析。结果实验组与对照组的口腔健康行为习惯比较差异具有统计学意义(P<0.05)。实验组与对照组年龄、菌斑指数、龋失补牙面数(DMFS)、简化口腔卫生指数(OHI-S)、唾液皮质醇浓度的比较差异均具有统计学意义(P<0.05)。实验组中女性唾液皮质醇浓度高于男性,差异有统计学意义(P<0.05),对照组中男女性唾液皮质醇浓度差异无统计学意义(P>0.05)。实验组唾液皮质醇浓度与年龄、性别、吸烟史、牙石指数(CI)呈正相关,与口腔卫生、菌斑指数、DMFS及软垢指数(DI)无相关性,对照组中唾液皮质醇浓度与年龄、性别、吸烟史呈正相关,与其他因素无相关性。结论①抑郁症患者唾液皮质醇浓度明显高于健康人群。②唾液皮质醇浓度变化可能与龋病的发生、发展存在一定相关性。

Objective To investigate the correlation between saliva cortisol concentration and caries in depressed patients.Methods Collecting confirmed depression(experimental group)and the healthy check-up people(control group)morning 8 to 10 when resting state under natural mixed saliva secretion 3 ml,using Enzyme Linked Immunosorbent Assay(ELISA)to calculate two groups cortisol concentration in saliva,through the form of questionnaire survey to assess their mental state,and general oral cavity,record data and statistical analysis.Results There were statistically significant differences in oral health behaviors between the experimental group and the control group(P<0.05).There were statistically significant differences in age,plaque index,decayed-missingfilled surface(DMFS),simplified oral hygiene index(OHI-S)and salivary cortisol concentration between the experimental group and the control group(P<0.05).In the experimental group,the salivary cortisol concentration of women was higher than that of men,and the difference was statistically significant(P<0.05);in the control group,the salivary cortisol concentration of men and women was not statistically significant(P>0.05).In the experimental group,salivary cortisol concentration was positively correlated with age,gender,smoking history and calculus index(CI),but not correlated with oral hygiene,plaque index,DMFS,debris index(DI).In the control group,salivary cortisol concentration was positively correlated with age,gender and smoking history,but not correlated with other factors.Conclusion①The salivary cortisol concentration in depressed patients was significantly higher than that in healthy people.②The variation of saliva cortisol concentration may be correlated with the occurrence and development of dental caries.