自身免疫性脑炎相关癫癎功能影像学研究进展

Progress in functional imaging of autoimmune encephalitis associated with epilepsy

自身免疫性脑炎相关癫癎是一组重要的临床综合征,主要表现为难治性癫癎发作、认知功能障碍和精神症状,经早期诊断和免疫治疗后可获得良好预后,因此尽早诊断、及时治疗至关重要。随着神经影像学技术特别是功能影像学的发展,逐渐显现出显著的临床应用价值,在疾病诊断和预后评估中具有重要作用。通过综述国内外自身免疫性脑炎相关癫癎功能影像学研究进展,为早期识别、鉴别诊断和预后评估提供影像学依据。

Autoimmune encephalitis(AE)associated with epilepsy is a significant clinical syndrome,which is characterized by refractory seizures,cognitive deficits,neuropsychiatric disturbances.Many studies have been clearly notified that early diagnosis combined with immunotherapy can apparently improve prognosis,thus early diagnosis and treatment are highly essential.In recent years,the neuroimaging,especially functional imaging,plays a critical role in the early diagnosis and prognostic assessment of AE associated with epilepsy.This review summarized the methods and results of functional imaging in the diagnosis of epilepsy associated with AE,to provide an imaging basis for clinical and differential diagnosis and prognostic assessment.